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ProteomicsSomatostatin-interacting human brain proteins
Somatostatin (SST) is a cyclic peptide that is understood to inhibit the release of hormones and neurotransmitters from a variety of cells by binding to one of five canonical G protein-coupled SST receptors (SSTR1 to SSTR5). Recently, SST was observed to also interact with the amyloid beta (Aβ) pept...
ORGANISM(S): Homo sapiens (Human) 
2019-04-04 | PXD010885 | Pride
Somatostatin Brain Alzheimer disease Human Orbitrap Amyloid beta Neuroendocrine Biotinylation Endocrine Interactome 
TranscriptomicsGene expression profiling of neuroendocrine primary tumors: effect of Octreotide treatment
The management of neuroendocrine tumors (NETs) is very variable, depending on many specific aspects, such as the type of tumor, spread and patient general health. Several advances have been made with the newly developed somatostatin analogues to cure this type of malignancies. Somatostain analogues ...
ORGANISM(S): Homo sapiens 
2012-12-12 | E-GEOD-24358 | biostudies-arrayexpress
TranscriptomicsNeuropeptides:developmental signals in placode progenitor formation
Few families of signaling factors have been implicated in the control of development. Here we identify the neuropeptides nociceptin and somatostatin, a neurotransmitter and neuroendocrine hormone, as a class of developmental signals in chick and zebrafish. We show that signals from the anterior mese...
ORGANISM(S): Gallus gallus 
2014-04-25 | E-GEOD-48116 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of wild type and somatostatin 3 CrispR/Cas9 zebrafish mutants treated with dextran sodium sulfate (DSS)
Wild type and somatostatin 3 (Sst3) gene CrispR/Cas9 mutants of the AB zebrafish strain were treated with dextran sodium sulfate (DSS) to determine the role of sst3 in the innate immune response.
ORGANISM(S): Danio rerio 
2020-07-31 | E-MTAB-9018 | biostudies-arrayexpress
GenomicsRegulation of retinal neurogenesis by somatostatin signaling
Regulation of retinal neurogenesis by somatostatin signaling
PRJNA691881 | ENA
TranscriptomicsRNA-Seq of CRISPR/Cas9 zebrafish somatostatin 6 (sst6) mutant embryos at 0, 3 and 6 hours post fertilization compared to wild type controls
sst6 follows Tostivint et al 2019 gene naming (doi:10.1016/j.ygcen.2019.02.022). The experiment intended to identify the main transcript differences between the zebrafish somatostatin 6 mutants and wild type at 0, 3 and 6 hours post fertilization, as well as to identify maternal and zygotic activate...
ORGANISM(S): Danio rerio 
2026-06-30 | E-MTAB-15099 | biostudies-arrayexpress
GenomicsTranscriptional alterations in Nucleus Accumbens somatostatin interneurons following exposure to cocaine
Transcriptional alterations in Nucleus Accumbens somatostatin interneurons following exposure to cocaine
PRJNA478793 | ENA
GenomicsTargeting somatostatin receptors by functionalized mesoporous silica nanoparticles.
Targeting somatostatin receptors by functionalized mesoporous silica nanoparticles.
PRJEB23155 | ENA
GenomicsNova proteins direct synaptic integration of somatostatin interneurons through activity- dependent alternative splicing
Nova proteins direct synaptic integration of somatostatin interneurons through activity- dependent alternative splicing
PRJNA600006 | ENA
TranscriptomicsPatchSeq experiment on somatostatin-expressing (Sst) neurons from mouse ventral tegmental area (VTA). Full-length single cell sequencing.
Experiment was done as a part of multi-methodological description of Sst-neurons subtypes in mouse VTA, aiming to reveal their transcriptional profiles and neurotransmitter nature.
ORGANISM(S): Mus musculus 
2020-06-02 | E-MTAB-8780 | biostudies-arrayexpress
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