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ProteomicsFrontiers in Plasma Proteome Profiling Platforms: Innovations and Applications.
Biomarkers play a crucial role in advancing precision medicine by enabling more targeted and individualized approaches to diagnosis and treatment. Various biofluids, including serum, plasma, cerebrospinal fluid (CSF), saliva, tears, pancreatic cyst fluids, and urine, have been identified as rich sou...
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD050425 | Pride
Biomarker Sp100 instrument Biofluids proteome profiling Preomics-ist Seer proteograph Timstofpro2 Secretome Plasma proteome 
ProteomicsPhospholipids with two polyunsaturated fatty acyl tails drive ferroptosi.
Phospholipids containing polyunsaturated fatty acyl tails (PL-PUFAs) are susceptible to lipid peroxidation by reactive oxygen species, lipoxygenases, and radical species. The accumulation of peroxidized lipids in cell membranes overwhelms endogenous lipid repair processes and triggers ferroptosis. W...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD041993 | Pride
Polyunsaturated fatty acid  pufa  phospholipid  mitochondria  complex i  ros  ferroptosis  lipids 
ProteomicsFerroptosis inhibition by oleic acid mitigates iron-overload-induced injury.
Iron overload, characterized by accumulation of iron in tissues, induces a multiorgan toxicity whose mechanisms are not fully understood. Using cultured cell lines, Caenorhabditis elegans, and mice, we found that ferroptosis occurs in the context of iron-overload-mediated damage. Exogenous oleic aci...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD045642 | Pride
C. elegans Oleic acid ferroptosi 
ProteomicsDigly analysis of human Kv7.1 transfected in HEK293 cells. 
Polyubiquitin chain diversity generates a ‘ubiquitin code’ that universally regulates protein functional expression but functions of polyubiquitin diversity are mostly unknown. Using digly mass spectrometry, we have evaluated the basal polyubiquitin diversity on Kv7.1 ion channels expressed with a C...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD057805 | Pride
Kv7.1 ion channel Nedd4l Itch Polyubiquitin Protein degradation Ubiquitin code 
UnknownUrotensin II system in chronic kidney disease.
Not available
S-EPMC11109353 | biostudies-literature
ProteomicsHeart failure-induced cognitive dysfunction is mediated by intracellular Ca2+ leak through ryanodine receptor type 2.
Cognitive dysfunction (CD) in heart failure (HF) adversely affects treatment compliance and quality of life. Although, ryanodine receptor type 2 (RyR2) has been linked to cardiac muscle dysfunction, its role in CD remains unclear. Here, we show in hippocampal neurons from patients and mice with HF t...
ORGANISM(S): Mus musculus (Mouse) 
2023-08-30 | PXD042295 | Pride
Calcium Cognitive dysfunction Heart failure Ryanodine receptor 
MetabolomicsDietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism

Ferroptosis is mediated by lipid peroxidation of phospholipids containing polyunsaturated fatty acyl moieties. Glutathione, the key cellular antioxidant capable of inhibiting lipid peroxidation via the activity of the enzyme glutathione peroxidase 4 (GPX-4), is generated directly from the sulfur-...

2023-01-11 | MTBLS5959 | MetaboLights
UnknownPreliminary model assessing the cost-effectiveness of preoperative chlorhexidine mouthwash at reducing postoperative pneumonia among abdominal surgery patients in South Africa.
Not available
S-EPMC8360544 | biostudies-literature
UnknownDeath following pulmonary complications of surgery before and during the SARS-CoV-2 pandemic.
Not available
S-EPMC10364875 | biostudies-literature
UnknownImpact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries.
Not available
S-EPMC10783642 | biostudies-literature
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