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TranscriptomicsHypothalamic gene expression profile indicates a reduction in G-protein signaling in the wfs1 mutant mice
WFS1 gene is coding protein with unknown function but its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study we aimed to find the functional networks influenced by the Wfs1 deficiency in the hypothalamus. We performed gene expression profiling ...
ORGANISM(S): Mus musculus 
2011-11-02 | E-GEOD-33372 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of temporal lobes of wfs1 deficient mice
Aim of present study was to describe the changes induced deletion of the Wfs1 gene in the temporal lobe of mice. Mutant mice were backcrossed to two different genomic backgrounds in order to exclude confounding foreign genomic background influence. Samples from temporal lobes were analyzed by using ...
ORGANISM(S): Mus musculus 
2010-04-06 | E-GEOD-15293 | biostudies-arrayexpress
TranscriptomicsSilencing of the WFS1 gene in HEK cells induces pathways related to neurodegeneration and mitochondrial damage.
The gene WFS1 encodes a protein with unknown function although its functional deficiency causes different neuropsychiatric and neuroendocrine syndromes. In the present study, we aimed to find the functional networks influenced by the time-dependent silencing of WFS1 in HEK cells. We performed whole ...
ORGANISM(S): Homo sapiens 
2012-09-05 | E-GEOD-40585 | biostudies-arrayexpress
TranscriptomicsPeripheral blood RNA expression profiling in illicit methcathinone users reveals effect on immune system
Methcathinone (ephedrone) is relatively easily accessible for abuse. Its users develop an extrapyramidal syndrome and it is not known if this is caused by methcathinone itself, by side-ingredients (manganese), or both. In the present study we aimed to clarify molecular mechanisms underlying this con...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-28686 | biostudies-arrayexpress
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