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ProteomicsPhotoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatial-temporal resolution in live cells
Proximity labeling (PL) characterizes protein interactome in living cells. However, exogenous H2O2 required for engineered peroxidase, like APEX2, is cytotoxic, while biotin ligases-based PL have poor temporal resolution. Here, we showed that SOPP3, an engineered photosensitizer, could trigger APEX2...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055708 | Pride
Proximity labeling Apex2 Sopp3 Protein-protein interaction Photosensitizer 
ProteomicsPhotoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells
Proximity labeling (PL) characterizes protein interactome in living cells. However, exogenous H2O2 required for engineered peroxidase, like APEX2, is cytotoxic, while biotin ligases-based PL have poor temporal resolution. Here, we showed that SOPP3, an engineered photosensitizer, could trigger APEX2...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD055722 | Pride
Proximity labeling Apex2 Sopp3 Protein-protein interaction Photosensitizer 
ProteomicsGenetically encoded photocatalytic protein labeling enables spatially-resolved profiling of intracellular proteome
Mapping the subcellular organization of proteins is crucial for understanding their biological functions. Herein, we report a reactive oxygen species induced protein labeling and identification (RinID) method for profiling subcellular proteome in the context of living cells. Our method capitalizes o...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD037678 | Pride
Minisog sopp3 proximity labeling photosensitive protein singlet oxygen 
UnknownPhotoactivated SOPP3 enables APEX2-mediated proximity labeling with high spatio-temporal resolution in live cells.
Not available
S-EPMC11770099 | biostudies-literature
UnknownGenetically Encoded Photosensitizers as Light-Triggered Antimicrobial Agents.
Not available
S-EPMC6769541 | biostudies-literature
UnknownTargeted photodynamic neutralization of SARS-CoV-2 mediated by singlet oxygen.
Not available
S-EPMC9906597 | biostudies-literature
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