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We discovered that cellular uptake of sorbate, an FDA-approved and widely used food preservative, can induce lysine sorbylation (Ksor), a new posttranslational modification and epigenetic mark. Proteomics analysis identified over 20 histone sorbylation sites in cells and mouse liver as well as over ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-04-22 | PXD058007 | Pride
1000 mg/L potassium sorbate-exposed Drosophila melanogaster gut microbiota Raw sequence reads
Environmental factors may affect gene expression through epigenetic modifications of histones and transcription factors. Here, we report that cellular uptake of sorbate, a common food preservative, induces lysine sorbylation (Ksor) in mammalian cells and tissue mediated by the noncanonical activitie...
ORGANISM(S): Mus musculus 
2026-05-30 | GSE297972 | GEO
Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expressin of inflammation genes.
HFHL Dietary Sorbate
Deciphering the response mechanism to sorbate in high-solids anaerobic digestion of food waste Raw sequence reads
Genomics
potassium sorbate mice
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