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ProteomicsIdentification of lysine sorbylation
We discovered that cellular uptake of sorbate, an FDA-approved and widely used food preservative, can induce lysine sorbylation (Ksor), a new posttranslational modification and epigenetic mark. Proteomics analysis identified over 20 histone sorbylation sites in cells and mouse liver as well as over ...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-04-22 | PXD058007 | Pride
Sorbate Hdac Sorbylation Lysine acylation 
TranscriptomicsGenome-wide analysis of the epigenetic effects of histone sorbylation in HepG2 cells [RNA-seq]
We investigated the epigenetic effects of histone sorbylation induced by potassium sorbate treatment in HepG2 hepatocellular carcinoma cells. RNA-seq analysis revealed that sorbate treatment caused diverse changes in gene expression, with significant upregulation of cholesterol biosynthetic genes. C...
ORGANISM(S): Homo sapiens 
2026-10-15 | GSE286104 | GEO
GenomicsGenome-wide analysis of the epigenetic effects of histone sorbylation in HepG2 cells [CUT&Tag]
We investigated the epigenetic effects of histone sorbylation induced by potassium sorbate treatment in HepG2 hepatocellular carcinoma cells. RNA-seq analysis revealed that sorbate treatment caused diverse changes in gene expression, with significant upregulation of cholesterol biosynthetic genes. C...
ORGANISM(S): Homo sapiens 
2026-10-15 | GSE286103 | GEO
GenomicsSorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expressin of inflammation genes.
Sorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expressin of inflammation genes.
PRJNA1267052 | ENA
TranscriptomicsSorbate induces lysine sorbylation through noncanonical activities of class I HDACs to regulate the expressin of inflammation genes.
Environmental factors may affect gene expression through epigenetic modifications of histones and transcription factors. Here, we report that cellular uptake of sorbate, a common food preservative, induces lysine sorbylation (Ksor) in mammalian cells and tissue mediated by the noncanonical activitie...
ORGANISM(S): Mus musculus 
2026-05-30 | GSE297972 | GEO
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