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ProteomicsSoluble SORLA enhances neurite outgrowth and regeneration through activation of EGFR and MAPK pathways
SORLA is a type I transmembrane component associated with Alzheimers disease (AD) risk. Although SORLA is abundantly expressed in neurons, physiological roles for SORLA remain yet unclear. Here, we show that cultured neurons overexpressing SORLA (SORLA TG) feature enhanced neurite length, and accele...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2020-05-12 | MSV000085400 | MassIVE
ProteomicsSORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain
A role for the type I transmembrane trafficking receptor SORLA in reducing Aβ levels has been well-established, however, virtually nothing is known with respect to whether and how SORLA can potentially affect tau pathology. Here, we show that transgenic SORLA upregulation (SORLA TG) can reverse path...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-24 | PXD056276 | Pride
Tauopathy Alzheimer’s disease Tau Plexin Semaphorin Sorla Tau pathology 
GenomicsCharacterizing transcriptomic profiles with human SORLA overexpression in mice
Characterizing transcriptomic profiles with human SORLA overexpression in mice
PRJNA631680 | ENA
GenomicsSORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain [GeoMX]
SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain [GeoMX]
PRJNA1165322 | ENA
GenomicsSORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain [snRNA-seq]
SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain [snRNA-seq]
PRJNA1166116 | ENA
OtherSORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain [GeoMX]
A role for the type I transmembrane trafficking receptor SORLA in reducing Aβ levels has been well-established, however, virtually nothing is known with respect to whether and how SORLA can potentially affect tau pathology. Here, we show that transgenic SORLA upregulation (SORLA TG) can reverse path...
ORGANISM(S): Mus musculus 
2026-05-24 | GSE278067 | GEO
TranscriptomicsSORLA upregulation suppresses global pathological effects in aged tauopathy mouse brain [snRNA-seq]
A role for the type I transmembrane trafficking receptor SORLA in reducing Aβ levels has been well-established, however, virtually nothing is known with respect to whether and how SORLA can potentially affect tau pathology. Here, we show that transgenic SORLA upregulation (SORLA TG) can reverse path...
ORGANISM(S): Mus musculus 
2026-05-24 | GSE278215 | GEO
TranscriptomicsCharacterizing transcriptomic profiles with human SORLA overexpression in mice
The purpose of this study is to determine global changes in mRNA expression with transgenic expression of human SORLA in mouse hippocampus
ORGANISM(S): Mus musculus 
2020-05-12 | GSE150257 | GEO
UnknownSORLA attenuates EphA4 signaling and amyloid β-induced neurodegeneration.
Not available
S-EPMC5716044 | biostudies-literature
UnknownSORLA regulates endosomal trafficking and oncogenic fitness of HER2.
Not available
S-EPMC6538630 | biostudies-literature
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