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MetabolomicsThe Impacts of Sortase A and the 4'-Phosphopantetheinyl Transferase Homolog Sfp on Streptococcus mutans Extracellular Membrane Vesicle Biogenesis

Extracellular membrane vesicles (EMVs) are produced by many Gram-positive organisms, but information regarding vesiculogenesis is incomplete. We used single gene deletions to evaluate the impacts on Streptococcus mutans EMV biogenesis of Sortase A (SrtA), which affects S. mutans...

2021-10-06 | MTBLS1812 | MetaboLights
ProteomicsStructural and Functional Interrogation of Active Streptococcus pneumoniae Sortase A
Sortase A (SrtA) enzymes covalently anchor surface proteins to Gram-positive bacterial cell walls, promoting colonization and virulence. In Streptococcus pneumoniae, previous studies identified both a domain-swapped dimer and an active refolded monomer, but the active enzyme has not been characteriz...
ORGANISM(S): Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) 
2026-10-05 | PXD082607 | Pride
Enzyme Sortase-a  streptococcus pneumoniae  nmr  lc-ms/ms 
ProteomicsProfiling N-myristoyltransferase activity and inhibition in breast cancer cells (MD-MB-231) using Sortase-A labelling
We report a novel application for Sortase A (SrtA), labeling N-terminal Gly proteins across the proteome at endogenous levels. We combined SrtA labeling of whole-cell lysates with a potent and selective NMT inhibitor, delivering a method capable of quantifying changes in cellular NMT activity in mul...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD010634 | Pride
Sortase a  srta  n-myristoylation  nmt 
GenomicsThe transpeptidase sortase A, binds nucleic acids, which can be used and to mediates their cell labeling
The transpeptidase sortase A, binds nucleic acids, which can be used and to mediates their cell labeling
PRJNA984672 | ENA
TranscriptomicsThe transpeptidase sortase A, binds nucleic acids, which can be used and to mediates their cell labeling
We found the transpeptidase Sortase A also binds nucleic acids and mediates mammalian cell labeling. We confiremed the labeling reaction using . Furthermore, a variety of additional classes of wild-type sortase and engineered mutants of sortase A exhibited the ability to label the surface of mammali...
ORGANISM(S): Homo sapiens Mus musculus 
2024-04-10 | GSE235152 | GEO
UnknownCrystal structure of Streptococcus pyogenes sortase A: implications for sortase mechanism.
Not available
S-EPMC2652338 | biostudies-literature
UnknownSortase B, a new class of sortase in Listeria monocytogenes.
Not available
S-EPMC374393 | biostudies-literature
UnknownBicyclic Engineered Sortase A Performs Transpeptidation under Denaturing Conditions.
Not available
S-EPMC10288436 | biostudies-literature
UnknownStructure and function of a Clostridium difficile sortase enzyme.
Not available
S-EPMC4371152 | biostudies-literature
UnknownThe Transpeptidase Sortase A Binds Nucleic Acids and Mediates Mammalian Cell Labeling.
Not available
S-EPMC11151058 | biostudies-literature
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