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TranscriptomicsListeria monocytogenes SOS response determined after mitomycin C exposure
The SOS response is a conserved pathway that is activated under certain stress conditions and is regulated by the repressor LexA and the activator RecA. The food-borne pathogen Listeria monocytogenes contains RecA and LexA homologs, but their roles in Listeria have not been established. In this stud...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-05-19 | E-GEOD-12634 | biostudies-arrayexpress
ProteomicsMechanistic Divergence Between SOS Response Activation and Antibiotic-Induced Plasmid Conjugation in E. coli
Project description: Plasmids, frequently carried by environmental and pathogenic bacteria, play a critical role in rapid dissemination of antibiotic resistance through conjugation. The use of antibiot-ics further induces this conjugative transmission between bacteria and thereby plays a role in the...
ORGANISM(S): Escherichia coli 
2025-05-08 | PXD063721 | Pride
Sos response  conjugation  antibiotics  e. coli  inci1 
MetabolomicsMetabolic response to point mutations reveals principles of modulation of in vivo enzyme activity and phenotype
The relationship between sequence variation and phenotype is poorly understood. Here, we use metabolomic analysis to elucidate the molecular mechanism underlying the filamentous phenotype of E. coli strains that carry destabilizing mutations in dihydrofolate reductase (DHFR). We find that partial lo...
2021-06-30 | MTBLS2795 | MetaboLights
ModelsShimoni2009 - Escherichia Coli SOS
Shimoni2009 - Escherichia Coli SOS Simple model, involving only the basic components of the circuit, sufficient to explain the peaks in the promoter activities of recA and lexA. This model is described in the article: Stochastic...
2005-01-01 | MODEL2937159804 | BioModels
TranscriptomicsHuman subcutaneous adipose tissue gene expression (SOS Sib-pair study, offspring cohort)
Obesity has considerable effects on morbidity and mortality, and the prevalence of obesity has been increasing rapidly worldwide during the past two decades. Even if obesity affects the entire individual, adipose tissue plays a central role in the development of obesity. Expression profiling of adip...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-27916 | biostudies-arrayexpress
no omics definedTranscription profiling time series of Pseudomonas aeruginosa wild type and lexA mutant response to treatment with ciprofloxacin
Pseudomonas aeruginosa infections can be virtually impossible to eradicate and the evolution of resistance during antibiotic therapy is a significant concern. In this study, we use DNA microarrays to characterize the global transcriptional response of P. aeruginosa to clinical-like doses of the ant...
ORGANISM(S): Pseudomonas aeruginosa 
2007-09-21 | E-GEOD-5443 | biostudies-arrayexpress
GenomicsAbrogation of SOS mutagenesis by the E. coli OxyR oxidative stress response
Abrogation of SOS mutagenesis by the E. coli OxyR oxidative stress response
PRJNA1422737 | ENA
TranscriptomicsMEK Inhibition Overcomes Cisplatin Resistance Conferred by SOS/MAPK Pathway Activation in Squamous Cell Carcinoma (SCC)
Genomic analyses of SCC have yet to yield significant strategies against pathway activation to improve treatment. Platinum-based chemotherapy remains the mainstay of treatment for SCC of different histotypes either as a single agent or alongside other chemotherapeutic drugs or radiotherapy; however,...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-66549 | biostudies-arrayexpress
TranscriptomicsDpiA overexpression
The dpiA and dpiB genes of Escherichia coli, which are orthologs of genes that regulate citrate uptake and utilization in Klebsiella pneumoniae, comprise a two-component signal transduction system that can modulate the replication of and destabilize the inheritance of pSC101 and certain other plasmi...
ORGANISM(S): Escherichia coli 
2006-01-30 | E-GEOD-4112 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Escherichia coli overexpressing dpiA vs wt
The dpiA and dpiB genes of Escherichia coli, which are orthologs of genes that regulate citrate uptake and utilization in Klebsiella pneumoniae, comprise a two-component signal transduction system that can modulate the replication of and destabilize the inheritance of pSC101 and certain other plasmi...
ORGANISM(S): Escherichia coli 
2005-12-06 | E-SMDB-3557 | biostudies-arrayexpress
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