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TranscriptomicsStimulation of BL2 cell line with lipopolysaccharide (LPS) for 6h
Identification of genes up or down regulated in LPS stimulated samples in comparison to control samples. 3 LPS stimulated samples vs. 3 controls were analyzed
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-29700 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [FFPE]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48182 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [Frozen tissue]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48183 | biostudies-arrayexpress
TranscriptomicsMolecular classification of mature aggressive B cell lymphoma using digital multiplexed gene expression on formalin-fixed paraffin-embedded biopsy specimens [Affymetrix]
The most frequent mature aggressive B-cell lymphomas are diffuse large B-cell lymphoma (DLBCL) and Burkitt lymphoma (BL). Patients suffering from molecularly defined BL (mBL) but treated with a regimen developed for DLBCL show an unfavorable outcome compared to mBL treated with chemotherapy regimens...
ORGANISM(S): Homo sapiens 
2013-09-25 | E-GEOD-48097 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of Sunitinib-treated but not untreated short-term serum-free cultures predict treatment response of human high-grade gliomas in vitro
High-grade gliomas are amongst the most deadly human tumors. Treatment results are overall disappointing. Nevertheless, in several trials around 20% of patients respond to therapy. Diagnostic strategies to identify those patients that will ultimately profit from a specific targeted therapy are urgen...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-51305 | biostudies-arrayexpress
TranscriptomicsAnalyzing synergistic and non-synergistic interactions in signalling pathways using Boolean Nested Effect Models
Understanding the structure and interplay of cellular signalling pathways is one of the great challenges in molecular biology. Boolean Networks can infer signalling networks from observations of protein activation. In situations where it is difficult to assess protein activation directly, Nested Eff...
ORGANISM(S): Homo sapiens 
2015-12-10 | E-GEOD-68761 | biostudies-arrayexpress
TranscriptomicsTranscriptome partitioning in mouse fertilization.
RNA transcripts are distributed non-uniformly in the oocytes of many animals, such that newly-divided embryo cells (blastomeres) inherit distinct transcriptomes following fertilization. In animals such as the frog, Xenopus laevis, programmed transcript regionalization directs early embryonic axis fo...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-27396 | biostudies-arrayexpress
TranscriptomicsValidation study: Response-predictive gene expression profiling of glioma progenitor cells in vitro
Background. In a previous publication we introduced a novel approach to identify genes that hold predictive information about treatment outcome. A linear regression model was fitted by using the least angle regression algorithm (LARS) with the expression profiles of a construction set of 18 glioma p...
ORGANISM(S): Homo sapiens 
2016-02-21 | E-GEOD-76990 | biostudies-arrayexpress
TranscriptomicsGene expression changes in subclones of a Burkitt lymphoma cell line with different patterns of EBV latent infection
In this study we have investigated the gene expression profiles of three different types of subclone all generated by single cell cloning of the same parental EBV positive Burkitt lymphoma cell line Awia-BL. These included EBV negative clones which have lost the virus episome, EBV positive clones w...
ORGANISM(S): Homo sapiens 
2013-01-22 | E-GEOD-42867 | biostudies-arrayexpress
TranscriptomicsDeep sequencing of MYC DNA-binding sites in Burkitt's lymphoma
Background: MYC is a transcription factor encoded by the c-MYC gene (thereafter termed MYC). MYC is key transcription factor involved in many central cellular processes including ribosomal biogenesis. MYC is overexpressed in the majority of human tumours including aggressive B-cell lymphoma especial...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-30726 | biostudies-arrayexpress
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