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TranscriptomicsSimple combinations of lineage-determining transcription factors prime cis-regulatory elements required for macrophage and B cell identities
Genome-scale studies have revealed extensive co-localization of transcription factors in a given cell type as well as substantial differences in the binding patterns of specific transcription factors between cell types. Several mechanisms have been proposed to explain these observations, including t...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-21512 | biostudies-arrayexpress
GenomicsRemodeling of the enhancer landscape during macrophage activation is coupled to enhancer transcription
Recent studies suggest a hierarchical model in which lineage-determining factors act in a collaborative manner to select and prime cell-specific enhancers, thereby enabling signal-dependent transcription factors to bind and function in a cell type-specific manner. Consistent with this model, TLR4 si...
ORGANISM(S): Mus musculus 
2013-08-09 | E-GEOD-48759 | biostudies-arrayexpress
TranscriptomicsMechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes (Illumina sequencing data)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies tha...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-23619 | biostudies-arrayexpress
GenomicsRetinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling [SREBP]
Data from SREBP1c binding to the genome was visualized using Genome Browser (UCSC) in order to test its role in Mafb transcriptional regulation SREBP ChIP was performed in thioglycollate-elicited peritoneal macrophages treated as indicated.
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-63697 | biostudies-arrayexpress
GenomicsGenome-wide chromatin-immunoprecipitation studies of purified SAN cells reveals critical direct targets of ISL1 and suggests potential co-factor families for ISL1 action in SAN cells
Understanding factors that drive development and function of the sinoatrial node (SAN) is crucial to development of potential therapies for sinus arrhythmias, including potential generation of biological pacemakers. Here, we identify a key cell autonomous role for the LIM homeodomain transcription f...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-68974 | biostudies-arrayexpress
GenomicsRetinoid X receptors orchestrate osteoclast differentiation and postnatal bone remodeling [RXR and PPARg]
Data from nuclear receptors RXR and PPARg binding to the genome was visualized using Genome Browser (UCSC) in order to test their role in Mafb transcriptional regulation RXR and PPARg ChIP was performed in thioglycollate-elicited peritoneal macrophages in basal conditions
ORGANISM(S): Mus musculus 
2015-02-04 | E-GEOD-63696 | biostudies-arrayexpress
GenomicsNCoR Repression of LXRs Restricts Macrophage Biosynthesis of Insulin-Sensitizing Omega 3 Fatty Acids
Macrophage-mediated inflammation is a major contributor to obesity-associated insulin resistance. The corepressor NCoR interacts with inflammatory pathway genes in macrophages, suggesting that its removal would result in increased activity of inflammatory responses. Surprisingly, we find that macrop...
ORGANISM(S): Mus musculus 
2013-10-09 | E-GEOD-50944 | biostudies-arrayexpress
TranscriptomicsMechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes (Agilent expression data)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies tha...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-23620 | biostudies-arrayexpress
TranscriptomicsMechanisms Establishing TLR4-Responsive Activation States of Inflammatory Response Genes (Illumina expression data)
Precise control of the innate immune response is required for resistance to microbial infections and maintenance of normal tissue homeostasis. Because this response involves coordinate regulation of hundreds of genes, it provides a powerful biological system to elucidate the molecular strategies tha...
ORGANISM(S): Mus musculus 
2011-01-01 | E-GEOD-23621 | biostudies-arrayexpress
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