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ProteomicsDeepPlaque: A scalable platform for multimodal investigation of Aβ pathology and brain cell analysis in Alzheimer’s disease
This is a study for the development and application of DeepPlaque system, consisting of a deep learning model for amyloid plaque detection and classification, with two application workflow for spatial cellular phenotyping and proteomics profiling of amyloid niches and neighboring cells.
ORGANISM(S): Homo sapiens (Human) 
2026-07-17 | PXD071421 | Pride
Spatial proteomics Alzheimer’s disease Deep learning model Spatial cellular phenotyping Postmortem brain samples 
ProteomicsSpatial Proteomics of a human brain tumour
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD039159 | Pride
Spatial Laser capture microdissection Proteomics 
ProteomicsSpatial Proteomics of a Human Brain Tumour
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD039398 | Pride
Spatial Laser capture microdissection Proteomics Maldi imaging 
ProteomicsSpatial Proteomics of a Human Brain Tumour at 40 µm resolution
The spatial organisation of Cellular protein expression profiles within tissues determines cellular function and are key to understanding disease pathology. To define molecular phenotypes in the spatial context of tissue, there is a need for unbiased, quantitative technology capable of mapping prote...
ORGANISM(S): Homo sapiens (Human) 
2023-10-10 | PXD044714 | Pride
Spatial proteomics Laser capture microdissection Roteomics 
UnknownSpatial phenotyping of human bronchial airways in obstructive lung disease.
Not available
S-EPMC12224523 | biostudies-literature
UnknownResolving phenotyping discordance with SPACEMAP, an integrated machine learning framework.
Not available
S-EPMC12707289 | biostudies-literature
UnknownA machine learning approach toward automating spatial identification of LAG3+/CD3+ cells in ulcerative colitis.
Not available
S-EPMC10709428 | biostudies-literature
UnknownDeep cell phenotyping and spatial analysis of multiplexed imaging with TRACERx-PHLEX.
Not available
S-EPMC11180132 | biostudies-literature
UnknownSpatial Analysis of the Tumor Microenvironment in Diffuse Large B-cell Lymphoma Reveals Clinically Relevant Cell Interactions and Recurrent Cellular Neighborhoods.
Not available
S-EPMC12485370 | biostudies-literature
UnknownCellular cartography of the organ of Corti based on optical tissue clearing and machine learning.
Not available
S-EPMC6338463 | biostudies-literature
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