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TranscriptomicsTranscription profiling of rat hippocampus DG region after spatial learning training
A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a...
ORGANISM(S): Rattus norvegicus 
2008-06-18 | E-GEOD-11475 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampus from animals subjected to a spatial learning profile
A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a...
ORGANISM(S): Rattus norvegicus 
2008-06-18 | E-GEOD-11474 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat hippocampus from young and aged rats with age-related spatial learning impairments
The aim of this study was to investigate whether the differences in memory decline associated with aging are a result of differences in gene expression. We first categorized age-unimpaired and age-impaired rats based on their performance in the Morris Water Maze and then isolated messenger RNA from...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3531 | biostudies-arrayexpress
MetabolomicsTargeted metabolomic profiling and machine learning-based prediction models for persistent atrial fibrillation: a multi-center observational study

Background. Atrial fibrillation (AF), the most common cardiac arrhythmia worldwide, carries a high risk of severe complications. Patients diagnosed with paroxysmal atrial fibrillation (PAF) may progress to persistent atrial fibrillation (PerAF) following a period. We aimed to identify metabo...

2026-07-03 | MTBLS13136 | MetaboLights
TranscriptomicsTranscriptional profile of mice with good and poor spatial learning during West Nile virus recovery
Greater than 50% of patients who survive neuroinvasive West Nile virus (WNV), a mosquito-borne, positive-sense strand flavivirus, exhibit cognitive sequelae including memory impairments which may last several years. High survival rates from WNV neuroinvasive disease (WNND) (>90%) have led to hundred...
ORGANISM(S): Mus musculus 
2016-06-27 | E-GEOD-72139 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat CA3 region of the hippocampus following control task or spatial modelling task
A theoretical framework for the function of the medial temporal lobe system in memory defines differential contributions of the hippocampal subregions with regard to pattern recognition retrieval processes and encoding of new information. To investigate molecular programs of relevance, we designed a...
ORGANISM(S): Rattus norvegicus 
2008-06-18 | E-GEOD-11473 | biostudies-arrayexpress
ProteomicsPhosphoproteomics of tau from tau knockout mice expressing tau in hippocampal neurons during spatial reference learning
This dataset describes the mass spectrometric identification of phosphorylation sites on tau protein isolated from the hippocampus of tau knockout (tau‑/‑) mice during spatial reference learning. Tau expression was selectively reintroduced into hippocampal neurons using adeno‑associated viral (AAV) ...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-04-10 | PXD076789 | Pride
Hippocampus Spatial reference learning Tau Phosphoproteomics 
TranscriptomicsGBM-Space: Spatial Transcriptomic Profiling of Glioblastoma (10x Genomics - Visium)
Cancer cells display highly heterogeneous and plastic states in glioblastoma, an incurable brain tumour. However, how these malignant states arise and whether they follow defined cellular trajectories across tumours is poorly understood. Here, we generated a deep single cell and spatial multi-omic a...
ORGANISM(S): Homo sapiens 
2026-09-12 | E-MTAB-17164 | biostudies-arrayexpress
Transcriptomics10X Visium spatial RNA-seq from adult mouse brain sections paired to single-nucleus RNA-seq
We developed cell2location, a principled and versatile Bayesian model that is designed to resolve fine-grained cell types in spatial transcriptomic data and create comprehensive cellular maps of diverse tissues. To validate cell2location in real tissue, we applied the model to data from the mouse br...
ORGANISM(S): Mus musculus 
2021-11-12 | E-MTAB-11114 | biostudies-arrayexpress
TranscriptomicsBehaviorally activated mRNA expression profiles produce signatures of learning and enhanced inhibition in aged rats with preserved memory
Aging is often associated with cognitive decline, but many elderly individuals maintain a high level of function throughout life. Here we studied outbred rats, which also exhibit individual differences across a spectrum of outcomes that includes both preserved and impaired spatial memory. Previous w...
ORGANISM(S): Rattus norvegicus 
2013-12-16 | E-GEOD-47867 | biostudies-arrayexpress
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