Natural killer (NK) cells eliminate target cells by forming an immunological synapse (IS). This process, however, is frequently thwarted by their “kiss-and-run” behavior characterized by transient, abortive interactions. Here, we equip NK cell with multivalent ligands that resemble prehensile “arms”...
Spatiotemporal proteomics reveals the biosynthetic lysosomal membrane protein interactome in neurons. Lysosomes are membrane-bound organelles critical for maintaining cellular homeostasis. Delivery of biosynthetic lysosomal proteins to lysosomes is crucial to orchestrate proper lysosomal function. H...
