Sort   by:  
 Page size 
MetabolomicsMetabolome variability for two Mediterranean sponge species of the genus Haliclona: specificity, time, and space

INTRODUCTION: The study of natural variation of metabolites brings valuable information on the physiological state of the organisms as well as their phenotypic traits. In marine organisms, metabolome variability has mostly been addressed through targeted studies on metabolites of...

2021-10-27 | MTBLS638 | MetaboLights
MetabolomicsPlasma Lipid Profile Reveals Plasmalogens as Potential Biomarkers for Colon Cancer Screening

In this era of precision medicine, there is an increasingly urgent need for highly sensitive tests for detecting tumors such as colon cancer (CC), a silent disease where the first symptoms may take 10-15 yr to appear. Mass spectrometry-based lipidomics is an emerging tool for such clinical diagno...

2023-11-13 | MTBLS1584 | MetaboLights
MetabolomicsUHPLC-OE-MS metabolic profile of follicular fluid in patients with ovarian endometriosis: a pilot study of an endometriosis cohort

BACKGROUND: Endometriosis is a common benign gynaecological disorder. A number of studies have confirmed that the occurrence of disease in endometriosis patients is associated with metabolic changes in biological fluids and tissues. We set out to investigate the metabolic charact...

2024-02-20 | MTBLS8621 | MetaboLights
GenomicsAsymmetry of STAT action in driving IL-27 and IL-6 transcriptional outputs and cytokine specificity
IL-6 and IL-27 have antagonistic and overlapping functions, signal through a shared receptor subunit and employ the same downstream STAT proteins. To evaluate the degree of specificity and redundancy for these cytokines, we quantified global transcriptomic changes induced by the two cytokines and de...
ORGANISM(S): Mus musculus 
2015-05-27 | E-GEOD-65621 | biostudies-arrayexpress
TranscriptomicsEffects of HMGN variants on cellular transcription profile
HMGN (high mobility group N) is a family of intrinsically disordered nuclear proteins that binds to nucleosomes, alters the structure of chromatin and affects transcription. A major unresolved question is the extent of functional specificity, or redundancy, between the various members of the HMGN p...
ORGANISM(S): Mus musculus 
2011-02-28 | E-GEOD-27546 | biostudies-arrayexpress
TranscriptomicsResponsiveness of genes to manipulation of transcription factors in ES cells is associated with chromatin structure and tissue specificity
Background: In addition to determining static states of gene expression (high vs. low), it is important to characterize their dynamic status. For example, genes with H3K27me3 chromatin marks are not only suppressed but also poised for activation. However, the responsiveness of genes to perturbations...
ORGANISM(S): Mus musculus 
2011-02-14 | E-GEOD-22151 | biostudies-arrayexpress
MetabolomicsHuman milk as infantile Super Food - the effect of dietary choices and supplementation on the shift of lipidomic profile during different stages of lactation
The objective of this project was to establish an advanced analytical method leveraging high-resolution mass spectrometry LC-HRMS to comprehensively profile the human milk lipidome. Mass spectrometry resolves and quantifies compounds based on a fundamental physical metric: the mass-to-charge ratio. ...
2026-09-22 | MTBLS15678 | MetaboLights
ProteomicsDirect in-gel profiling of protease specificity (DIPPS)
Determination of protease specificity is of crucial importance for understanding protease function. We have developed the first gel-based label-free proteomic approach (DIPPS) that enables quick and reliable determination of protease cleavage specificities under large variety of experimental conditi...
ORGANISM(S): Aeropyrum pernix Homo sapiens (Human) 
2017-07-06 | PXD004218 | Pride
Specificity profiling Protease Legumain Cathepsin Degradomics 
TranscriptomicsGene-expression profile comparisons distinguish seven organs of maize
A maize array was fabricated with 5,376 unique expressed sequence tag (EST) clones sequenced from 4-day-old roots, immature ears and adult organ cDNA libraries. To elucidate organ relationships, relative mRNA levels were quantified by hybridization with embryos, three maize vegetative organs (leaf b...
ORGANISM(S): Zea mays 
2003-01-07 | E-GEOD-141 | biostudies-arrayexpress
GenomicsSingle Alkyl Phosphonate Modification of the siRNA Backbone in the Seed Region Enhances Specificity and Therapeutic Profile
Single Alkyl Phosphonate Modification of the siRNA Backbone in the Seed Region Enhances Specificity and Therapeutic Profile
PRJNA1205781 | ENA
Sort   by:  
 Page size