Sort   by:  
 Page size 
TranscriptomicsStudy of SPEN overexpression in T47D cells. (2)
We investigated the functions/pathways affected by SPEN in breast cancer by global expression profiling in a cell model, where the human breast cancer cell line, T47D, were transfected with an expression vector coding for SPEN.
ORGANISM(S): Homo sapiens 
2015-10-21 | E-MTAB-2182 | biostudies-arrayexpress
TranscriptomicsStudy of SPEN knockdown in MCF-7 cells. (2)
We investigated the functions/pathways affected by SPEN knockdown in breast cancer by global expression profiling in a cell model, where the human breast cancer cell line, MCF-7, were transfected with an shRNA targeting SPEN mRNA.
ORGANISM(S): Homo sapiens 
2015-10-21 | E-MTAB-2183 | biostudies-arrayexpress
TranscriptomicsStudy of SPEN knockdown in MCF10A cells
In this experiment, we knocked down the expression of Split Ends (SPEN), a gene that we found was involved in the regulation of primary cilia formation, in MCF10A cells, to evaluate its effects on transcription. Split Ends (SPEN) is a transcriptional coregulator that have formerly identified as a t...
ORGANISM(S): Homo sapiens 
2017-08-15 | E-MTAB-4974 | biostudies-arrayexpress
TranscriptomicsEffect of estradiol and tamoxifen on SPEN-expressing and control T47D cells.
Split Ends (SPEN) is a transcriptional coregulator that have formerly identified as a tumour suppressor gene in ER-positive breast cancers. However, ER-positive breast cancers are diagnosed at similar frequencies in pre- and post-menopausal women who show significantly different circulating hormone ...
ORGANISM(S): Homo sapiens 
2017-08-15 | E-MTAB-4975 | biostudies-arrayexpress
ProteomicsSPEN is a molecular integrator that bridges Xist with transcriptional and epigenetic control of X-chromosome inactivation
Xist represents a paradigm for long non-coding RNA function in epigenetic regulation, although how it mediates X-chromosome inactivation (XCI) remains largely unexplained. Multiple Xist-RNA binding proteins have recently been identified, including SPEN/SHARP, whose knockdown has been associated with...
ORGANISM(S): Mus musculus (Mouse) 
2021-04-19 | PXD015699 | Pride
Xci X-chromosome inactivation Epigenetic Xist Spen 
GenomicsSpen regulates X chromosome inactivation (RNAseq in SPEN KO embryos)
Spen regulates X chromosome inactivation (RNAseq in SPEN KO embryos)
PRJNA548354 | ENA
GenomicsSpen regulates X chromosome inactivation (SPEN SPOC domain rescue)
Spen regulates X chromosome inactivation (SPEN SPOC domain rescue)
PRJNA763795 | ENA
GenomicsSpen regulates X chromosome inactivation (CUT&RUN)
Spen regulates X chromosome inactivation (CUT&RUN)
PRJNA544936 | ENA
GenomicsPolysome seq of treated with Enzalutamide and untreated (DMSO)prostate cancer cell line with SPEN wt and SPEN KO
Polysome seq of treated with Enzalutamide and untreated (DMSO)prostate cancer cell line with SPEN wt and SPEN KO
PRJNA1285687 | ENA
GenomicsSpen regulates X chromosome inactivation (RNAseq in ESCs )
Spen regulates X chromosome inactivation (RNAseq in ESCs )
PRJNA548359 | ENA
Sort   by:  
 Page size