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ProteomicsSignaling proteins of a chemosensory pathway from sperm of Arbacia punctulata
Cilia and flagella serve as cellular antennae that translate sensory information into cellular responses. In sperm, a single chemoattractant molecule triggers signaling events that evoke a Ca2+ response and chemotactic steering. Key components of the chemotactic signaling pathway from sperm of the s...
ORGANISM(S): Arbacia punctulata 
2019-12-11 | PXD015332 | Pride
Mudpit Sds-page lc-ms/ms Sperm Signal transduction Sea urchin 
ProteomicsChaperonin TRiC bridges radial spokes for folding proteins locally translated in mammalian sperm flagella
As animals evolved from external to internal fertilization, sperm flagella, which once transiently propelled sperm in water to reach nearby eggs, developed to beat for days or even longer within the female reproductive tract. How flagella were remodeled accordingly remains unclear. Unlike externally...
ORGANISM(S): Bos Taurus 
PXD067693 |
ProteomicsLoss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella
Aberrant sperm flagella impair sperm motility and cause male infertility, yet the genes which have been identified in multiple morphological abnormalities of the flagella (MMAF) can only explain the pathogenic mechanisms of MMAF in a small number of cases. Here, we identify and functionally characte...
ORGANISM(S): Mus musculus (Mouse) 
2019-11-12 | PXD011730 | Pride
Mutation Sperm flagella Morphological abnormalities Proteomics analysis 
ProteomicsDe novo protein identification in mammalian sperm using high-resolution in situ cryo-electron tomography
Understanding molecular mechanisms of cellular pathways regularly requires knowledge of the identities of participating proteins, their cellular localization and their 3D structures. Contemporary workflows typically require multiple techniques to identify target proteins, track their localization us...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-21 | PXD036885 | Pride
Global protein abundance In situ cryoet Mouse sperm axoneme Sperm flagella Visual proteomics 
ProteomicsLrrc23 WT and KO whole sperm proteomic analysis
LRRC23 is required for stablizing the sperm axonemal structure. Mass spectrometry analysis was carried out to compare the proteome of Lrrc23 WT and KO sperm.
ORGANISM(S): Mus musculus (Mouse) 
2021-11-02 | PXD025166 | Pride
Lrrc23 Sperm flagella 
Proteomicsquantitative proteomics analysis of Styxl1-/- mouse sperm
In order to investigate the molecular mechanism of Styxl1 in the regulation of sperm flagella, sperm from Styxl1+/+ and Styxl1-/- mice were collected for quantitative proteomics analysis using TMT-based liquid chromatography-tandem mass spectrometry (LC-MS/MS) approach. A total of 6429 proteins were...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-01 | PXD046203 | Pride
Styxl1 Sperm Quantitative proteomics Tmt Mouse 
UnknownBranchial cilia and sperm flagella recruit distinct axonemal components.
Not available
S-EPMC4427456 | biostudies-literature
GenomicsThe effect of ionomycin-induced oocyte activation on multiple morphological abnormalities of the sperm flagella
The effect of ionomycin-induced oocyte activation on multiple morphological abnormalities of the sperm flagella
PRJNA894516 | ENA
UnknownLoss-of-function mutations in QRICH2 cause male infertility with multiple morphological abnormalities of the sperm flagella.
Not available
S-EPMC6347614 | biostudies-literature
ProteomicsProteome analyses of sperm from wild type, Akap3 and Akap4 gene null mutant mice
PKA signaling plays important functions during mouse spermatogenesis and for the regulation of sperm motility. The efficiency of PKA signaling is regulated partly by its binding protein A-kinase anchoring protein (AKAP) family. Mature mouse sperm contain several AKAPs, of which AKAP3 and AKAP4 are...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-14 | PXD016928 | Pride
Mouse sperm  spermiogenesis  akap3  akap4  fibrous sheath 
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