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ProteomicsA Tiered Approach to Human Synapse Proteomics: Optimized LC-MS/MS Analysis of Whole-Tissue Lysate and Synaptosome Preparations from Frozen Post-Mortem Brain Samples
Recent advancements in neuroproteomics have enabled detailed analysis of protein expression and function in the human brain, improving our understanding of the relationship between genetics, cell biology of neurological and psychiatric disorders and their clinical diagnosis. Synaptic dysfunction oft...
ORGANISM(S): Homo sapiens (Human) 
2026-05-25 | PXD076278 | Pride
TranscriptomicsMajor Depressive Disorder blood gene expression
Background: Major Depressive Disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are not available. Methods: We used a classifier approach on blood gene expression profiles of a unique set of non-medicated su...
ORGANISM(S): Homo sapiens 
2011-10-04 | E-GEOD-19738 | biostudies-arrayexpress
TranscriptomicsSynaptic activity-regulated gene expression_embryonic day 18
Activity-dependent changes in synapses rely on functional changes in resident proteins and on gene expression. We addressed the relationship between synapse activity and the expression of synaptic genes by comparing RNA levels in the neocortex of normal mice versus synaptically silent munc18-1 null ...
ORGANISM(S): Mus musculus 
2006-07-31 | E-GEOD-3639 | biostudies-arrayexpress
UnknownGroup cognitive behavioural therapy and weight regain after diet in type 2 diabetes: results from the randomised controlled POWER trial.
Not available
S-EPMC6448975 | biostudies-literature
UnknownDe novo HNF4A-associated atypical Fanconi renal tubulopathy syndrome.
Not available
S-EPMC10920409 | biostudies-literature
UnknownImpulsivity and comorbid traits: a multi-step approach for finding putative responsible microRNAs in the amygdala.
Not available
S-EPMC4263087 | biostudies-literature
UnknownCause-specific mortality in Spain during the pandemic: educational differences and its impact on life expectancy.
Not available
S-EPMC10234659 | biostudies-literature
UnknownEducational differences in alcohol-related mortality and their impact on life expectancy and lifespan variation in Spain (2016-2018): a cross-sectional analysis using multiple causes of death.
Not available
S-EPMC8788229 | biostudies-literature
UnknownThe contribution of social participation to differences in life expectancy and healthy years among the older population: A comparison between Chile, Costa Rica and Spain.
Not available
S-EPMC7954322 | biostudies-literature
UnknownGenetic Variation in CNS Myelination and Functional Brain Connectivity in Recombinant Inbred Mice.
Not available
S-EPMC7564997 | biostudies-literature
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