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MetabolomicsTargeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury

Background: After spinal cord injury (SCI), lipid metabolism dysregulation at the lesion site exacerbates secondary damage. The transcription factor pu.1 has been implicated as a negative regulator of multiple lipid metabolism-related genes and pathways. However, its role in post-SCI lipid metabo...

2024-08-08 | MTBLS10453 | MetaboLights
TranscriptomicsDanio spinal cord injury
Adult zebrafish have the ability to recover from spinal cord injury and exhibit re-growth of descending axons from the brainstem to the spinal cord. We performed gene expression analysis using microarray to find damage-induced genes after spinal cord injury, which shows that Sox11b mRNA is up-regula...
ORGANISM(S): Danio rerio 
2010-10-19 | E-GEOD-20460 | biostudies-arrayexpress
TranscriptomicsDifferential Response Following Spinal Cord Injury in EphA4 Knockout
Mice lacking the developmental axon guidance molecule EphA4 have previously been shown to exhibit extensive axonal regeneration and functional recovery following spinal cord injury. To assess mechanisms by which EphA4 may modify the response to neural injury, a microarray was performed on spinal co...
ORGANISM(S): Mus musculus 
2012-05-23 | E-GEOD-34430 | biostudies-arrayexpress
TranscriptomicsTime series gene expression data from adult rat tail MNs following spinal cord transection
Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearance of plateau potentials in m...
ORGANISM(S): Rattus norvegicus 
2010-05-27 | E-GEOD-19701 | biostudies-arrayexpress
TranscriptomicsExpression data from adult rat tail MNs after spinal cord transection
Spinal cord injury leads to impaired motor and sensory functions. After spinal cord injury there is a an initial phase of hypo-reflexia followed by a developing hyper-reflexia, often termed spasticity. Previous studies have suggested a relationship between the reappearence of plateau potentials in m...
ORGANISM(S): Rattus norvegicus 
2009-10-31 | E-GEOD-16710 | biostudies-arrayexpress
TranscriptomicsTranscription profiling time series analyzing the molecular events in rat spinal cord sections following mechanical injury
Summary: Spinal cord injury (SCI) is a damage to the spinal cord induced by trauma or disease resulting in a loss of mobility or feeling. SCI is characterized by a primary mechanical injury followed by a secondary injury in which several molecular events are altered in the spinal cord often resulti...
ORGANISM(S): Rattus norvegicus 
2007-09-04 | E-GEOD-464 | biostudies-arrayexpress
TranscriptomicstrkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)
We profiled spinal cord tissue at the site of a moderate contusion injury at the level of the thoracic spinal cord We examined several timepoints following injury, including sham and days 1,3 and 7 following injury and compared differential expression of genes within a genotype and across genotypes ...
ORGANISM(S): Mus musculus 
2013-08-05 | E-GEOD-47681 | biostudies-arrayexpress
TranscriptomicsSpinal cord injury (RNA sequencing data)
We investigated the gene expression profile of monocyte-derived macrophages and microglia following spinal cord injury. Moreover, we investigated the gene expression profole of M-CSF induced macrophages and new-born derived microglia following TGFb1 treatment. monocyte-derived macrophages and microg...
ORGANISM(S): Mus musculus 
2014-12-03 | E-GEOD-62698 | biostudies-arrayexpress
TranscriptomicsExpression data from adult wistar female rat 5mm spinal cord tissue
We used microarray gene expression analyses to unveil the mechanisms underlying NT-3-chitosan-induced spinal cord regeneration. Complete transaction of thoracic spinal cord at T7/8 was performed, with a 5 mm segment of the spinal cord being removed. The emptied space where either refilled with a 5mm...
ORGANISM(S): Rattus norvegicus 
2015-11-02 | E-GEOD-69334 | biostudies-arrayexpress
ProteomicsPROTEOMIC IDENTIFICATION OF SYSTEMIC BIOMARKERS IN RAT MODELS OF SPINAL CORD INJURY
Biomarkers to more accurately determine severity and prognosis following spinal cord injury (SCI) are needed to ensure that patients are assigned to the most suitable treatment and rehabilitation regimes. This study aimed to characterise the blood proteome following SCI in clinical rat injury models...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-19 | PXD021137 | Pride
Spinal cord injury  sci  itraq proteomics  complete transection sci  contusion sci 
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