Spinal cord lesion

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Unknown (973)
Transcriptomics (130)
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Methylation profiling (2)
Metabolomics (1)

Organisms

Mus musculus (68)
Rattus norvegicus (27)
Homo sapiens (19)
Danio rerio (11)
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Canis lupus familiaris (1)

Organisms

Mus musculus (52)
Rattus norvegicus (23)
Danio rerio (9)
Homo sapiens (9)
Macaca mulatta (2)
Canis lupus familiaris (2)
Monodelphis domestica (1)
Petromyzon marinus (1)

Repository

ENA (109)
geo (72)
biostudies-arrayexpress (69)
pride (9)
EGA (1)
jPOST (1)
MetaboLights (1)

Tissue

Spinal cord (3)
Cell culture (2)
Nerve cord (2)
Astrocyte (1)
Brain (1)

Disease

XCGD (1)
Lymphoblastic leukemia (1)
Spinal cord (1)
Spinal cord disease (1)
Wounds and Injuries (1)

Technology Type

Mass Spectrometry (9)
Shotgun proteomics (6)
Data-dependent acquisition (2)
SWATH MS (2)
Mass spectrometry (1)
Bottom-up proteomics (1)
Gel-based experiment (1)
Top-down proteomics (1)

Instrument Platform

Illumina NovaSeq 6000 (2)
Non (1)
None (1)
Illumina (1)
Illumina HiSeq 2000 (1)
Liquid Chromatography MS - positive - reverse phase (1)
Liquid Chromatography MS - negative - reverse phase (1)

Publication Date

2013 (17)
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2015 (12)
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2021 (10)
2010 (10)
2020 (8)
2016 (6)
2014 (6)
2022 (6)
2012 (5)
2011 (5)
2009 (4)
2017 (4)
2007 (3)
2018 (3)
2008 (2)
2006 (1)
2019 (1)

Metabolite Name

Adefovir Dipivoxil (Preveon, Hepsera) (1)
Indomethacin (Indocid, Indocin) (1)
MLS001148580-01!6ALPHA,9ALPHA-DIFLUOROPREDNISOLONE 21-ACETATE 17-BUTYRATE (1)
Toremifene Citrate (Fareston, Acapodene) (1)
[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate (1)
(+)-Cycloolivil 4'-O-¦Â-D-glucopyranoside (1)
(+)-Fasciculic acid B (1)
(+)-Lyoniresinol 2¦Á-O-¦Â-D-glucopyranoside (1)
(-)-Medicocarpin;Medicarpin 3-O-glucoside (1)
(-)-Syringaresinol-4-O-¦Â-D-glucopyranoside (1)
(-)-threo-Iso(homo)2-citrate;(-)-threo-1-Hydroxy-1,2,5-pentanetricarboxylic acid;1-Hydroxypentane-1,2,5-tricarboxylate;threo-(Homo)2-isocitrate (1)
(1)Benzopyrano(5,4,3-cde)(1,3)dioxolo(4,5-h)(1)benzopyran-5,11-dione, 1,2,3-trimethoxy- (1)
(1,3-Dihydroxy-6,8a-dimethyl-3-propan-2-yl-1,2,3a,4,5,8-hexahydroazulen-4-yl) 3,4-dimethoxybenzoate (1)
(10-Hydroxy-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-f]chromen-9-yl) (Z)-2-methylbut-2-enoate (1)
(11E)-11-Octadecenoic acid (1R,2S)-2-[[(Z)-9-hexadecenoyl]oxy]-1-methylpropyl ester (1)
(12Z)-9,10,11,14,15,16,17,18,19,20,21,22-Dodecahydro-5,8-ethenobenzo[20]annulene-2,4,6,24-tetrol (1)
(13S)-13-Ethoxy-1,2-dimethoxy-12-methyl-13H-[1,3]benzodioxolo[5,6-c]phenanthridine (1)
(14E)-11-hydroxy-14-(1H-imidazol-5-ylmethylidene)-2-methoxy-9-(2-methylbut-3-en-2-yl)-2,13,16-triazatetracyclo[7.7.0.01,13.03,8]hexadeca-3,5,7-triene-12,15-dione (1)
(14S)-9,20,21,25-Tetramethoxy-15-methyl-7,23-dioxa-15,30-diazaheptacyclo[22.6.2.23,6.18,12.114,18.027,31.022,33]hexatriaconta-1(30),3(36),4,6(35),8,10,12(34),18,20,22(33),24,26,28,31-tetradecaen-2-one (1)
(19E,21E,23E,25E,27E,29E,31E)-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,33,37-pentahydroxy-18,36-dimethyl-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-9,13,15-trione (1)
(19E,21E,23E,25E,27E,29E,31E)-17-[7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl]-1,3,5,7,33,37-hexahydroxy-18-methyl-9,13,15-trioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylate (1)
(1E,3Z)-buta-1,3-diene-1,2,4-tricarboxylate (1)
(1R)-1-[(4-hydroxyphenyl)methyl]-6-methoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium-7-ol (1)
(1R)-1-[[(2S,3R,11bS)-3-ethyl-9,10-dimethoxy-1,2,3,4,5,6,7,11b-octahydrobenzo[a]quinolizin-5-ium-2-yl]methyl]-7-methoxy-1,2,3,4-tetrahydroisoquinolin-2-ium-6-ol (1)
(1R,10R)-5-amino-14-oxido-14-oxo-13,15,18-trioxa-2,4,6,9-tetraza-14lambda5-phosphatetracyclo[8.8.0.03,8.012,17]octadeca-3(8),4-diene-7,11-dione (1)
(1R,14R,24S)-24-Methoxy-5,7,19,21,25-pentaoxa-13-azahexacyclo[12.11.0.02,10.04,8.015,23.018,22]pentacosa-2,4(8),9,15(23),16,18(22)-hexaene (1)
(1R,2'S,3'aS,12S,14S)-2',12-dimethylspiro[13-oxa-2,10,17-triazatetracyclo[10.3.2.02,11.04,9]heptadeca-4,6,8,10-tetraene-14,4'-3,3a-dihydro-2H-imidazo[1,2-a]indole]-1',3,16-trione (1)
(1R,2R,5R,8R,9S,10R,11S)-11-methyl-6-methylidene-16-oxo-15-oxapentacyclo[9.3.2.15,8.01,10.02,8]heptadecane-9-carboxylate (1)
(1R,2R,5S,8S,9S,10R,11R,12R,13S)-5,12,13-trihydroxy-11-methyl-6-methylidene-16-oxo-15-oxapentacyclo[9.3.2.15,8.01,10.02,8]heptadecane-9-carboxylate (1)
(1R,2R,6R,11S,13S,14R,21R)-7,19,23-Triazahexacyclo[9.9.1.11,13.12,6.07,21.014,19]tricosane (1)

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2025 (21)
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2024 (10)
2020 (8)
2022 (6)
2014 (6)
2018 (5)
2017 (5)
2016 (2)
2015 (2)
2019 (1)
2013 (1)

Study type

Transcription profiling by array (44)
RNA-seq of coding RNA (10)
Unknown experiment type (2)
Comparative genomic hybridization by array (2)
Transcription profiling by SAGE (1)
Animal - Single-cell sequencing (1)
Plant - High-throughput sequencing (1)
Cell line - One-color microarray (1)
Transcription profiling by RT-PCR (1)
Other (1)
ChIP-seq (1)
Methylation profiling by array (1)
Proteomic profiling by array (1)
RNA-seq of coding RNA from single cells (1)
RNA-seq of non coding RNA (1)

Release Date

2022 (133)
2021 (97)
2023 (97)
2025 (89)
2024 (88)
2020 (77)
2019 (64)
2018 (58)
2017 (53)
2015 (50)
2016 (45)
2014 (36)
2013 (33)
2012 (24)
2011 (20)
2026 (19)
2010 (17)
2009 (13)
2008 (11)
2006 (6)
2007 (5)
2004 (4)
2002 (2)
2005 (1)

Lab affiliation

Max Planck Institute for the Science of Light & Max-Planck-Zentrum für Physik und Medizin Division Biological Optomechanics Staudtstr. 2 91058 Erlangen Germany (2)
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Ahmedabad (1)
Laboratoire PRISM INSERM U1192 (1)
MaineHealth Institute for Research, Director, Proteomics and Lipidomics Core (1)
Max Planck Institute for Biophysical Chemistry; University Medical Center Goettingen (1)
Michel Salzet, Univ. Lille, Inserm, U-1192 - Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse-PRISM, F-59000 Lille, France (1)
Univ. Lille, Inserm, U-1192 - Laboratoire Protéomique, Réponse Inflammatoire et Spectrométrie de Masse-PRISM, F-59000 Lille, France (1)
Univ. Lille, Inserm, U1192 - Protéomique Réponse Inflammatoire Spectrométrie de Masse - PRISM, F-59000 Lille, France (1)

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Targeting transcription factor pu.1 for improving neurologic outcomes after spinal cord injury

Background: After spinal cord injury (SCI), lipid metabolism dysregulation at the lesion site exacerbates secondary damage. The transcription factor pu.1 has been implicated as a negative regulator of multiple lipid metabolism-related genes and pathways. However, its role in post-SCI lipid metabo...

2024-08-08 | MTBLS10453 | MetaboLights

Expression data from adult wistar female rat 5mm spinal cord tissue

We used microarray gene expression analyses to unveil the mechanisms underlying NT-3-chitosan-induced spinal cord regeneration. Complete transaction of thoracic spinal cord at T7/8 was performed, with a 5 mm segment of the spinal cord being removed. The emptied space where either refilled with a 5mm...

ORGANISM(S): Rattus norvegicus

2015-11-02 | E-GEOD-69334 | biostudies-arrayexpress

Danio spinal cord injury

Adult zebrafish have the ability to recover from spinal cord injury and exhibit re-growth of descending axons from the brainstem to the spinal cord. We performed gene expression analysis using microarray to find damage-induced genes after spinal cord injury, which shows that Sox11b mRNA is up-regula...

ORGANISM(S): Danio rerio

2010-10-19 | E-GEOD-20460 | biostudies-arrayexpress

Gene expression profiles in the spinal cord below the lesion level and influence of treadmill locomotor training

Traumatic spinal cord injury (SCI) often leads to loss of locomotor function. Neuroplasticity of spinal circuitry underlies some functional recovery and therefore represents a therapeutic target to improve locomotor function following SCI. However, the cellular and molecular mechanisms mediating neu...

ORGANISM(S): Rattus norvegicus

2013-11-27 | E-GEOD-52763 | biostudies-arrayexpress

Proteomic analysis of the spatiotemporal based molecular kinetics of acute spinal cord injury identifies a time- and segment-specific window for effective tissue repair.

Spinal cord injury (SCI) represents a major debilitating health issue with a direct socioeconomic burden on the public and private sectors worldwide. Although several studies have been conducted to identify the molecular progression of injury sequel due from the lesion site, still the exact underlyi...

ORGANISM(S): Rattus norvegicus (Rat)

2016-06-08 | PXD003375 | Pride

RNA-Seq characterization of spinal cord injury transcriptome in acute/subacute phases: a resource for understanding the pathology at the systems level

Purpose: Spinal cord injury (SCI) is a devastating neurological disease without effective treatment. To generate a comprehensive view of the mechanisms involved in SCI pathology, we applied RNA-sequencing (RNA-seq) technology to characterize the temporal changes in global gene expression after contu...

ORGANISM(S): Mus musculus

2013-08-22 | E-GEOD-45376 | biostudies-arrayexpress

Spinal cord injury (RNA sequencing data)

We investigated the gene expression profile of monocyte-derived macrophages and microglia following spinal cord injury. Moreover, we investigated the gene expression profole of M-CSF induced macrophages and new-born derived microglia following TGFb1 treatment. monocyte-derived macrophages and microg...

ORGANISM(S): Mus musculus

2014-12-03 | E-GEOD-62698 | biostudies-arrayexpress

trkB.T1 WT versus trkB.T1 KO expression data following spinal cord injury (SCI)

We profiled spinal cord tissue at the site of a moderate contusion injury at the level of the thoracic spinal cord We examined several timepoints following injury, including sham and days 1,3 and 7 following injury and compared differential expression of genes within a genotype and across genotypes ...

ORGANISM(S): Mus musculus

2013-08-05 | E-GEOD-47681 | biostudies-arrayexpress

Transcription profiling of rat lumbar spinal cord following ventral root avulsion in two inbred strains to investigate susceptibility to neurodegeneration

Gene expression profiling in rat lumbar spinal cord following ventral root avulsion in the two inbred rat strains.

ORGANISM(S): Rattus norvegicus

2006-08-15 | E-MEXP-671 | biostudies-arrayexpress

Gene expression data of C57BL/6, Il1a-knockout and Il1b-knockout mice at 24 hours after spinal cord injury

We have previously shown that Il1a-knockout (KO) mice exhibit rapid (at day 1) and persistent improvements in locomotion associated with reduced lesion volume compared with Il1b-KO mice and C57BL/6 controls after traumatic spinal cord injury (SCI). To investigate the mechanism by which Il1a mediates...

ORGANISM(S): Mus musculus

2015-06-27 | E-GEOD-70302 | biostudies-arrayexpress

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