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ProteomicsCAMK2D recruits RNF8-MAD2 complex to RNA splicing proteins for mitotic checkpoint activation in GBM
Glioblastoma (GBM) is a lethal brain tumor with remarkable intra-tumoral heterogeneity and therapeutic resistance which is linked to glioma stem cell (GSC). GSC contains unstable genome and elevated genomic instability could impair GSC self-renewal and tumorigenicity. In addition, GSC displays great...
ORGANISM(S): Homo Sapiens (human) 
2023-07-21 | PXD038123 | JPOST Repository
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Convey variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering based ...
2024-09-02 | BIOMD0000000187 | BioModels
ModelsIbrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant
Ibrahim2008 - Mitotic Spindle Assembly Checkpoint - Dissociation variant The Mitotic Spindle Assembly Checkpoint ((M)SAC) is an evolutionary conserved mechanism. This model incorporates the perspectives of three central control pathways, namely Mad1/Mad2 induced Cdc20 sequestering ...
2024-09-02 | BIOMD0000000186 | BioModels
ModelsHenze2017 - A Dynamical Model for Activating and Silencing the Mitotic Checkpoint
The spindle assembly checkpoint (SAC) is an evolutionarily conserved mechanism, exclusively sensitive to the states of kinetochores attached to microtubules. During metaphase, the anaphase-promoting complex/cyclosome (APC/C) is inhibited by the SAC but it rapidly switches to its active form followin...
2024-01-24 | MODEL1812210002 | BioModels
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
This dataset consists of 1 raw MS file and associated peak list and result file, acquired on an Orbitrap Elite mass spectrometer operated in Data Dependent Acquisition mode. The files are associated with a manuscript submitted for publication. Publication title: "JAK2-CHK2 signaling safeguards the ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-03-31 | MSV000087138 | MassIVE
ProteomicsJAK2-CHK2 signaling safeguards the integrity of the mitotic spindle assembly checkpoint and genome stability
Checkpoint kinase 2 (CHK2) plays an important role in safeguarding the mitotic progression, specifically the spindle assembly, though the mechanism of regulation remains poorly understood. Here, we identified a novel mitotic phosphorylation site on CHK2 Tyr156, and its responsible kinase JAK2. Expre...
ORGANISM(S): Homo sapiens (Human) 
2024-10-16 | PXD056821 | Pride
Phosphorylation Chk2 Lc-ms/ms 
ProteomicsJuxtaposition of Bub1 and Cdc20 on phosphorylated Mad1 during catalytic mitotic checkpoint complex assembly (IGX-MS data)
During metaphase, in response to improper kinetochore-microtubule attachments, the spindle assembly checkpoint (SAC) activates the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome (APC/C). The Mad1-Mad2 complex provides a catalytic platform for MCC assembly. Mad1-...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD031872 | Pride
Cell cycle  spindle assembly checkpoint  mad1  bub1  cdc20  mitotic checkpoint complex 
ProteomicsGreatwall kinase regulates SAC by controlling phosphorylation and activity of MPS1
The Greatwall/Mastl kinase is an essential gene, which regulates the phosphatase activity that counteracts the phosphorylation of Cdk1 substrates. Although Mastl-/- MEFs can enter mitosis, they are unable to complete mitosis due to chromosome segregation defects. Here, we show that Mastl is essentia...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD004882 | Pride
Greatwall kinase/mastl/cyclin-dependent kinase/knockout mice/cdk1/mps1/sac 
TranscriptomicsExpression Profiling of Inflammatory Breast Cancer Cells Treated with the Novel Histone Deacetylase Inhibitor, CG-1521
Studies of gene expression profiles using the whole genome wide microarray analysis in SUM149PT cells (ER-, p53mut) and SUM190PT cells (ER-, p53mut) when treated with 5 or 7.5 uM CG-1521 alone and in combination with 10 nM 17beta-estradiol. Comparisons between each treatment group provides evidence ...
ORGANISM(S): Homo sapiens 
2011-04-12 | E-GEOD-28542 | biostudies-arrayexpress
UnknownSpindle Size Scaling Contributes to Robust Silencing of Mitotic Spindle Assembly Checkpoint.
Not available
S-EPMC5018141 | biostudies-literature
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