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TranscriptomicsTranscription profiling of human intra-pulmonary airways and buccal mucosa to identify the effects of cigarette smoke on the human airway epithelial cell transcriptome
A number of studies have shown that cigarette smoking produces a field defect, such that genetic mutations induced by smoking occur throughout the lung and its intra and extra-pulmonary airways. Based on this concept, we have begun this study, which has as its goal the definition of the normal airwa...
ORGANISM(S): Homo sapiens 
2007-10-04 | E-GEOD-994 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human airway epithelial cells to investigate the reversible and permanent effects of tobacco smoke exposure
RNA was obtained from histologically normal bronchial epithelium of never, former, and current smokers undergoing fiberoptic bronchoscopy. Statistical analysis of the gene expression data identified gene differentially expressed between current and never smokers and classified these genes as irrever...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-7895 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human lung tissue from severe emphysema versus normal or mild emphysema human patients
Comparison of severely emphysematous tissue removed at lung volume reduction surgery to that of normal or mildly emphysematous lung tissue resected from smokers with nodules suspicious for lung cancer. Data obtained from the 18 patients with severe emphysema and 12 patients with mild/no emphysema. R...
ORGANISM(S): Homo sapiens 
2007-08-13 | E-GEOD-1650 | biostudies-arrayexpress
TranscriptomicsmRNA-seq of Human Airway Epithelial Cells
mRNA expression was profiled from pooled bronchial airway epithelial cell brushings (n=3 patients/pool) obtained during bronchoscopy from healthy never (NS) and current smokers (S) and smokers with (C) and without (NC) lung cancer 4 samples were sequened, each representing a pool of 3 patients. The...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-29006 | biostudies-arrayexpress
TranscriptomicsLarge airway epithelial cells from cigarette smokers with and without lung cancer undergoing flexible bronchoscopy in the operating room for resection of a suspicious lung nodule
mRNA expression was assayed from bronchial epithelial cell samples from smokers with and without lung cancer. A subset of the samples (2 of the lung cancer samples and 3 of the no cancer samples) were pooled and underwent whole transcriptome sequencing. The goals were to compare whole transcriptom...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-28835 | biostudies-arrayexpress
TranscriptomicsBronchial airway gene expression reflects a COPD-associated field of injury that changes with disease severity and is reversible with therapy
RNA was isolated from bronchial brushings obtained from current and former smokers with and without COPD. mRNA expression was profiled using Affymetrix Human Gene 1.0 ST Arrays. RNA isolated from bronchial brushings was processed and hybridized to Affymetrix Human Gene 1.0 ST Arrays. A total of 269 ...
ORGANISM(S): Homo sapiens 
2013-03-22 | E-GEOD-37147 | biostudies-arrayexpress
TranscriptomicsGene expression from bronchial and nasal epithelial cell samples of healthy current and never smokers.
mRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy and nasal epithelial cells collected by brushing the inferior turbinate from healthy current and never smoker volunteers in order to determine the relationship between smoking-related gene expression changes in b...
ORGANISM(S): Homo sapiens 
2011-03-14 | E-GEOD-16008 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression from bronchial epithelial cell samples of current and never smokers.
MicroRNA expression was assayed from bronchial epithelial cells collected via bronchoscopy from healthy current and never smoker volunteers in order to determine the effect of cigarette smoke exposure on airway epithelial microRNA expression Keywords: Global microRNA expression profiling Bronchial ...
ORGANISM(S): Homo sapiens 
2009-01-28 | E-GEOD-14634 | biostudies-arrayexpress
TranscriptomicsPI3K pathway activity in the normal airway of smokers with lung cancer, and in smokers with airway dysplasia
Cytologically normal airway epithelial samples were collected during bronchoscopy of current and former smokers. Subjects enrolled in this study were either under suspicion of having lung cancer, had dysplasia in their airway, or were a healthy current, former or never smoker. We supplemented existi...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-12815 | biostudies-arrayexpress
TranscriptomicsIdentification of miR-4423 as a Primate-Specific microRNA Highly Expressed in Ciliated Airway Epithelium and Associated with Lung Cancer
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-10-07 | E-GEOD-48798 | biostudies-arrayexpress
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