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ProteomicsA nowhere-to-hide mechanism ensures complete piRNA-directed LINE1 methylation
The mouse PIWI-interacting RNA (piRNA) pathway provides anti-transposon immunity to the developing male germline by directing transposon DNA methylation. The first step in this process is the recruitment of SPOCD1 to young LINE1 loci 1 followed in the second step by piRNA-mediated tethering of the P...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD060850 | Pride
Piwi proteins Pirna Spocd1 and tpr Germline Transposons 
ProteomicsA nowhere-to-hide mechanism ensures complete piRNA-directed LINE1 methylation
The mouse PIWI-interacting RNA (piRNA) pathway provides anti-transposon immunity to the developing male germline by directing transposon DNA methylation. The first step in this process is the recruitment of SPOCD1 to young LINE1 loci 1 followed in the second step by piRNA-mediated tethering of the P...
ORGANISM(S): Mus musculus (Mouse) 
2025-11-11 | PXD060851 | Pride
Piwi proteins Pirna Spocd1 and tpr Germline Transposons 
GenomicsWhole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
In the male mouse germline, PIWI-interacting RNAs (piRNAs), bound by the PIWI protein MIWI2 (PIWIL4), guide the DNA methylation of young active transposable elements (TEs) through SPOCD1. We find that SPOCD1 interacts with the nuclear pore protein TPR, and that this interaction is required to preven...
ORGANISM(S): Mus musculus 
2025-11-12 | E-MTAB-14862 | biostudies-arrayexpress
GenomicsWhole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
Whole genome DNA methylation of undifferentiated spermatogonia of postnatal day 14 (P14) wild-type and Spocd1-K464A (does not interact with TPR) homozygous mutant mice
PRJEB86017 | ENA
UnknownA nowhere-to-hide mechanism ensures complete piRNA-directed DNA methylation.
Not available
S-EPMC7618654 | biostudies-literature
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