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MetabolomicsLACTIN-V (Lactobacillus crispatus CTV-05) leads to microbial and immune modulation in pregnant women at risk of spontaneous preterm birth: FLIP-1 study

Preterm birth (PTB) remains a leading cause of neonatal morbidity and mortality, with no new preventive therapeutics introduced since the 1970s. Evidence increasingly implicates adverse vaginal microbiome-immune interactions in its aetiology. We report the effects of the live biotherapeutic, Lact...

2026-10-02 | MTBLS15899 | MetaboLights
ProteomicsHeterologous Expression of MBP-AtABC1K6-His in E. coli
Heterologous E. coli expression of AtABC1K6 tagged with maltose binding protein (MBP) and 6xHis tags revealed a spontaneous cleavage event of the recombinant protein during purification. Resulting bands were resolved on SDS-PAGE and excised for MS/MS identification. Mass spec-based identification of...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2022-03-02 | PXD030384 | Pride
Coq8 Kinase Spontaneous cleavage Ubib Abc1 
UnknownSpontaneous Cleavage at Glu and Gln Residues in Long-Lived Proteins.
Not available
S-EPMC9206231 | biostudies-literature
UnknownD-β-aspartyl residue exhibiting uncommon high resistance to spontaneous peptide bond cleavage.
Not available
S-EPMC4753488 | biostudies-literature
TranscriptomicsAn activating NLRC4 inflammasome mutation causes autoinflammation with recurrent macrophage activation syndrome
Inflammasomes are intracellular innate immune sensors that respond to pathogen and damage-associated signals with the proteolytic cleavage of caspase-1, resulting in IL-1_ and IL-18 secretion and macrophage pyroptosis. The discovery that heterozygous gain-of-function mutations in NLRP3 lead to overs...
ORGANISM(S): Homo sapiens 
2014-09-08 | E-GEOD-57253 | biostudies-arrayexpress
UnknownUnrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity.
Not available
S-EPMC10691344 | biostudies-literature
ProteomicsCold-induced urticarial autoinflammatoy syndrome related to factor XII activation
Early onset urticarial rash with systemic inflammatory symptoms are hallmarks of hereditary autoinflammatory diseases caused by gene mutations of the innate immune pathway, e.g. nucleotide receptor protein 3 (NLRP3). However, in many cases genetic tests are negative, suggesting the existence of unre...
ORGANISM(S): Homo sapiens (Human) 
2010-01-10 | PXD016341 | Pride
Cleavage Activation Factor xii 
ProteomicsExtracellular vesicles released from cortical neurons influence spontaneous activity of recipient neurons.
Extracellular vesicles (EVs) are membranous structures that cells release into the extracellular space. EVs carry various molecules such as proteins, lipids, and nucleic acids, and serve as specialized transporters to influence other cells. In the central nervous system, EVs have been linked to many...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-22 | PXD062783 | Pride
Hippocampus Synaptic activity Nmda receptor Extracellular vesicles Cortex 
ProteomicsProteome changes in retinal Mueller glial cells from a spontaneous equine model for autoimmune uveitis compared to healthy controls
Retinal Müller glial cells (RMG) play a central role in retinal neuroinflammation, actively participating in the immune response and adopting a dynamic inflammatory phenotype. However, the precise functions of RMG in retinal inflammation remain incompletely understood. In this study, we investigated...
ORGANISM(S): Equus caballus (Horse) 
2025-05-07 | PXD058170 | Pride
Quantitative label-free lc-ms/ms  retinal neuroinflammation  autoimmune uveitis  equine recurrent uveitis (eru)  spontaneous equine animal model  retinal mueller glial cells (rmg) 
UnknownMechanism of protein cleavage at asparagine leading to protein-protein cross-links.
Not available
S-EPMC7156126 | biostudies-literature
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