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TranscriptomicsMacrophage-restricted Interleukin-10 receptor-, but not IL-10 deficiency causes severe spontaneous colitis
Interleukin-10 (IL-10) is a pleiotropic anti-inflammatory cytokine produced and sensed by most hematopoietic cells. Genome wide association studies and experimental animal models point at a central role of the IL-10 axis in Inflammatory Bowel Diseases. Here we investigated the importance of intestin...
ORGANISM(S): Mus musculus 
2014-05-09 | E-GEOD-56444 | biostudies-arrayexpress
TranscriptomicsDietary calcium inhibits colitis development in HLA-B27 transgenic rats
Background and Aims: We have shown in several controlled rat and human infection studies that dietary calcium improves intestinal resistance and strengthens the mucosal barrier. Reinforcement of gut barrier function is also relevant for inflammatory bowel disease (IBD). Therefore, we investigated th...
ORGANISM(S): Rattus norvegicus 
2009-07-16 | E-GEOD-11022 | biostudies-arrayexpress
TranscriptomicsRole of REG 1 in Entamoeba histolytica colitis
Differential expression was used to access gene differences after Entamoeba histolytica infection. Entamoeba histolytica is an important diarrheal pathogen worldwide, and induces apoptosis of the intestinal epithelium as part of its disease process. Regenerating (REG) 1 protein is anti-apoptotic. ...
ORGANISM(S): Homo sapiens 
2011-05-24 | E-GEOD-23750 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse intestine in ENU mutagenesis mouse strains with missense mutations in Muc2 mucin and ER stress
Background; MUC2 mucin produced by intestinal goblet cells is the major component of the intestinal mucus barrier. MUC2 homo-oligomerizes intracellularly into large secreted polymers which give mucus its viscous properties. The inflammatory bowel disease (IBD) ulcerative colitis is characterized by...
ORGANISM(S): Mus musculus 
2008-04-06 | E-GEOD-9913 | biostudies-arrayexpress
TranscriptomicsDivergent influence of microRNA-21 deletion on murine colitis phenotypes [mRNA]
Background: MicroRNAs (miRNAs) acting as negative regulators of gene expression are differentially expressed in intestinal tissues of patients with inflammatory bowel disease (IBD). Assessing the functional role of miRNAs in murine models of colitis facilitates elucidating the role of specific miRN...
ORGANISM(S): Mus musculus 
2014-07-23 | E-GEOD-59648 | biostudies-arrayexpress
ProteomicsTesting serum specificity for bacterial antigens in a mouse model of spontaneous colitis
Identification of bacterial antigens within cecal bacterial lysate was performed by using serum antibodies from control and DC-LMP1/CD40 animals for immunoprecipitation followed by label-free liquid chromatography tandem mass spectrometry (LC-MS/MS). Serum antibodies were coupled to beads and incuba...
ORGANISM(S): Helicobacter hepaticus 
2021-02-25 | PXD018025 | Pride
Helicobacter hepaticus Spontaneous colitis 
UnknownDual-specificity phosphatase 6 regulates CD4+ T-cell functions and restrains spontaneous colitis in IL-10-deficient mice.
Not available
S-EPMC4363301 | biostudies-literature
TranscriptomicsGene expression analysis in proximal and distal colons of Lcn2-/- IL10-/- double knock-out mice.
Lcn2 is involved in host defense against pathogens, but the function in intestinal mucosal immunity and inflammation remains largely unknown. Genetic ablation of Lcn2 results in early-onset colitis and spontaneous emergence of right-sided colonic tumors in the setting of IL-10 deficiency (Lcn2-/-;IL...
ORGANISM(S): Mus musculus 
2016-03-30 | E-MTAB-4583 | biostudies-arrayexpress
UnknownDeletion of TLR5 results in spontaneous colitis in mice.
Not available
S-EPMC2075480 | biostudies-literature
UnknownGut Microbiota Contributes to Spontaneous Colitis in E3 Ligase Itch-Deficient Mice.
Not available
S-EPMC7811274 | biostudies-literature
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