Sort   by:  
 Page size 
MetabolomicsTFAM loss induces nuclear actin assembly upon mDia2 malonylation to promote liver cancer metastasis
The mechanisms underlying cancer metastasis remain poorly understood. Here, we report that TFAM deficiency rapidly and stably induced spontaneous lung metastasis in mice with liver cancer. Interestingly, unexpected polymerization of nuclear actin was observed in TFAM-knockdown HCC cells when cytoske...
2022-06-23 | MTBLS4307 | MetaboLights
TranscriptomicsTranscription profiling of mouse BALB/c strain animals injected with breast cancer 4T1-derived cells to investigate the role of epithelial to mesenchymal transition (EMT) in spontaneous breast cancer metastasis
Epithelial-mesenchymal transition (EMT) has been linked to cancer progression and metastatic propensity. The 4T1 tumor is a clinically relevant model of spontaneous breast cancer metastasis. Here we characterize 4T1-derived cell lines for EMT, in vitro invasiveness and in vivo metastatic ability. Co...
ORGANISM(S): Mus musculus 
2009-03-07 | E-GEOD-11259 | biostudies-arrayexpress
TranscriptomicsA novel preclinical mouse model of spontaneous breast cancer metastasis
Metastatic disease remains one of the most urgent clinical challenges accounting for over 90% of cancer-related deaths. Yet, the identification of novel therapeutic targets to fight or prevent metastatic disease has been hampered by the limited availability of clinically relevant mouse models of met...
ORGANISM(S): Mus musculus 
2011-12-23 | E-GEOD-34666 | biostudies-arrayexpress
ProteomicsDifferential Proteome Analysis of Human Neuroblastoma Xenograft Primary Tumors and Matched Spontaneous Distant Metastases
Metastasis formation is the major cause for cancer-related deaths and the underlying mechanisms remain poorly understood. In this study we describe spontaneous metastasis xenograft mouse models of human neuroblastoma used for unbiased identification of metastasis-related proteins by applying an infr...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-09-24 | PXD009744 | Pride
Bioluminescence imaging Proteome analysis Spontaneous metastasis Infrared laser ablation 
TranscriptomicsTranscription profiling of human prostate cancer primary cell line vs metastasis cell line reveals Protein 4.1B suppresses prostate cancer progression and metastasis
Protein 4.1B is a 4.1/ezrin/radixin/moesin (FERM) domain-containing protein whose expression is frequently lost in a variety of human tumors, including meningiomas, non-small-cell lung cancers and breast carcinomas. However, its potential tumor suppressive function under in vivo conditions remains t...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-7930 | biostudies-arrayexpress
TranscriptomicsA Molecular Signature Associated with Human Melanoma Brain Metastasis and Spontaneous Micrometastasis
We established a model of human melanoma metastasis to identify differentially expressed genes in brain metastasis, compared to cutaneous melanoma from which they were developed. Such genes may control brain metastasis. The identification and characterization of these genes would advance the underst...
ORGANISM(S): Homo sapiens 
2011-03-17 | E-GEOD-27980 | biostudies-arrayexpress
GenomicsMulti-omics approach to decipher Ewing sarcoma metastases using a spontaneous metastasis mouse model
Multi-omics approach to decipher Ewing sarcoma metastases using a spontaneous metastasis mouse model
PRJNA1027354 | ENA
TranscriptomicsComparison of matched primary and metastasis 4T1.2 syngeneic mammary tumor model of spontaneous bone metastasis
Breast cancer metastasis to bone is a critical determinant of long-term survival after treatment of primary tumors. We used a mouse model of spontaneous bone metastasis to determine new molecular mechanisms. Differential transcriptome comparisons of primary and metastatic tumor cells revealed that a...
ORGANISM(S): Mus musculus 
2012-07-17 | E-GEOD-37975 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of spontaneous metastasis in a K-ras/p53 mutant mouse model
The biologic basis for NSCLC metastasis is not well understood. Here we addressed this deficiency by transcriptionally profiling tumors from a genetic mouse model of human lung adenocarcinoma that develops metastatic disease owing to the expression of K-rasG12D and p53R172H. We identified 2,209 gene...
ORGANISM(S): Mus musculus 
2009-04-14 | E-GEOD-14449 | biostudies-arrayexpress
UnknownNeoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis.
Not available
S-EPMC6693253 | biostudies-literature
Sort   by:  
 Page size