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TranscriptomicsExpression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
This SuperSeries is composed of the following subset Series: GSE17058: MiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes GSE17059: Gene expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17060 | biostudies-arrayexpress
TranscriptomicsMiRNA expression in adipose tissue and liver from a spontaneous rat model of Type 2 diabetes
MicroRNAs (miRNAs) are non-coding RNA molecules involved in post-transcriptional control of gene expression of a wide number of genes, including those involved in glucose homeostasis. Type 2 diabetes (T2D) is characterized by hyperglycaemia and defects in insulin secretion and action at target tissu...
ORGANISM(S): Rattus norvegicus 
2010-05-16 | E-GEOD-17058 | biostudies-arrayexpress
MetabolomicsZhaqu Compound Improves Glucose and Lipid Metabolism in T2DM with MASLD by Modulating Gut Microbiota and PPARγ

Type 2 diabetes mellitus (T2DM) with metabolic syndrome-associated steatohepatitis (MASLD) is a complex metabolic comorbidity characterized by hyperglycemia, pancreatic β-cell dysfunction, and hepatic lipid metabolism disorders, in which gut microbiota dysbiosis and abnormal PPARγ signaling play ...

2026-02-25 | MTBLS13933 | MetaboLights
ProteomicsProteomic Atlas of Obesity and Type 2 Diabetes in Cynomolgus Monkeys
Obesity and type 2 diabetes (T2D) remain major global healthcare challenges and developing therapeutics necessitate using nonhuman primate models. Here, we present proteomic analyses of all the major organs of cynomolgus monkeys with spontaneous obesity or T2D in comparison to healthy controls.
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2023-06-23 | PXD036423 | Pride
Obesity Cynomolgus monkeys Type 2 diabetes 
OtherType 1 Diabetes Prone NOD Mice Have Diminished Cxcr1 mRNA Expression in Polymorphonuclear Neutrophils and CD4+ T Lymphocytes.
Data from ProteomeXchange, PXD ID: PXD003015. File: OB07268.mzml. Published as part of PLoS One. 2015 Jul 31;10(7):e0134365 . From the Abstract: {{i}} ... Here, we report descriptive data about the Cxcr1 gene in NOD mice ... {{/i}}
ORGANISM(S): Mus_musculus_viruses, Mouse 
GPM32310024995 | GPMDB
Resource Reanalysis 
TranscriptomicsNaturally transmitted segmented filamentous bacteria segregate with diabetes protection in NOD mice
Vertebrates typically harbor a rich gastrointestinal microbiota, which has co-evolved with the host over millennia and is essential for several of its physiological functions, in particular maturation of the immune system. Recent studies have highlighted the importance of a single bacterial species,...
ORGANISM(S): Mus musculus 
2011-06-09 | E-GEOD-29806 | biostudies-arrayexpress
ProteomicsSILAC-based quantitative proteomic analysis of the livers of spontaneous obese and diabetic rhesus monkeys
Type 2 diabetes mellitus (TM) is a severely metabolic disorder that affects above 10% worldwide population. Obesity is a major cause of insulin resistance and contributes to the development of TM. Liver is an essential metabolic organ that plays crucial roles in the pathogenesis of obesity and diabe...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2019-08-26 | PXD008825 | Pride
Spontaneous type 2 diabetes  liver  rhesus monkey  silac-based quantitative proteomics. 
TranscriptomicsThe role of insulin resistance in experimental diabetic retinopathy - genetic and molecular aspects
Patients with long-duration diabetes develop cardiovascular complications resulting in highly increased mortality and complications which affect the kidneys, eyes and peripheral nerves associated with high morbidity. Among the diabetic complications, damage in the eye, diabetic retinopathy, is the m...
ORGANISM(S): Rattus norvegicus 
2017-03-31 | E-MTAB-5563 | biostudies-arrayexpress
UnknownIncreased immune cell infiltration of the exocrine pancreas: a possible contribution to the pathogenesis of type 1 diabetes.
Not available
S-EPMC4207385 | biostudies-literature
UnknownProteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus.
Not available
S-EPMC5583949 | biostudies-literature
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