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ProteomicsSpry1 as a potential new hypoxia modulator in cutaneous melanoma
Introduction. At present, the precise role of Spry proteins in tumor progression is still debated. Our previous study showed that Spry1 knockdown (Spry1KO) in BRAFV600-mutant cutaneous melanoma (CM) promoted cell cycle arrest and apoptosis, repressed cell proliferation in vitro, and reduced tumor gr...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD038916 | Pride
Cutaneous melanoma Hypoxia Braf Ip-ms Spry1 
GenomicsDmrt1 maintains testicular immune homeostasis by activating Spry1 and inhibiting NF-κB signaling pathway [Spry1 KD RNA-Seq]
Dmrt1 maintains testicular immune homeostasis by activating Spry1 and inhibiting NF-κB signaling pathway [Spry1 KD RNA-Seq]
PRJNA876714 | ENA
GenomicsRNAseq profiling of back dermis from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
RNAseq profiling of back dermis from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
PRJNA1221800 | ENA
GenomicsSingle-cell RNA sequencing profiling of periarticular tissue from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
Single-cell RNA sequencing profiling of periarticular tissue from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
PRJNA1221796 | ENA
TranscriptomicsDmrt1 maintains testicular immune homeostasis by activating Spry1 and inhibiting NF-κB signaling pathway [Spry1 KD RNA-Seq]
To explore the function of Spry1 in testis, we constructed a mouse model with testicular specific KD of Spry1 through seminiferous tubule transplantation
ORGANISM(S): Mus musculus 
2023-09-01 | GSE212667 | GEO
TranscriptomicsRNAseq profiling of back dermis from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
Spry1 cKO mice were found spontaneously developed psoriasis-like skin inflammation and arthritis.To further investigate the gene expression differences between the back dermis of Spry1 cKO mice and control mice, RNAseq was performed.
ORGANISM(S): Mus musculus 
2025-05-27 | GSE289141 | GEO
TranscriptomicsSingle-cell RNA sequencing profiling of periarticular tissue from epidermal-specific SPRY1-deficient (Spry1 cKO) mice and control mice
Spry1 cKO mice were found spontaneously developed psoriasis-like skin inflammation and arthritis.To further investigate the periarticular immune microenvironment in paws, single-cell RNA sequencing of the periarticular tissue from Spry1 cKO and control mice was performed.
ORGANISM(S): Mus musculus 
2025-05-27 | GSE289142 | GEO
GenomicsADAP-METTL3 modulates the inflammatory responses of macrophages via m6A modification of Spry1
ADAP-METTL3 modulates the inflammatory responses of macrophages via m6A modification of Spry1
PRJNA1292201 | ENA
UnknownSpry1 and Spry2 are necessary for eyelid closure.
Not available
S-EPMC3857020 | biostudies-literature
OtherADAP-METTL3 modulates the inflammatory responses of macrophages via m6A modification of Spry1
While N6-methyladenosine (m6A) RNA modification is implicated in macrophage inflammatory responses, its regulatory mechanisms remain elusive. Our prior studies demonstrated that a deficiency in immune adaptor protein ADAP promotes inflammation in TLR4-stimulated macrophages. Here, we show that ADAP ...
ORGANISM(S): Mus musculus 
2025-12-02 | GSE302809 | GEO
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