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ProteomicsDoa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE
Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 structural analysis by cryo-EM and AlphaFold predictions, and a s...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD047499 | Pride
Ubiquitylation E3 ubiquitin ligases March6 Membrane proteins Doa10 Cryo-em Sqle 
Genomicsp53 transcriptionally regulates SQLE to modulate cholesterol synthesis and tumor growth
p53 transcriptionally regulates SQLE to modulate cholesterol synthesis and tumor growth
PRJNA734935 | ENA
GenomicsGene expression profiling of RKO cells with or without SQLE knockdown.
Gene expression profiling of RKO cells with or without SQLE knockdown.
PRJNA973571 | ENA
GenomicsRNA sequencing to determine gene expression changes in SQLE knockdown osteosarcoma cells
RNA sequencing to determine gene expression changes in SQLE knockdown osteosarcoma cells
PRJNA1028999 | ENA
GenomicsExpression data from human Bladder cancer cell line J82 with control or overexpression of SQLE
Expression data from human Bladder cancer cell line J82 with control or overexpression of SQLE
PRJNA962967 | ENA
Transcriptomicsp53 transcriptionally regulates SQLE to modulate cholesterol synthesis and tumor growth
Cholesterol is essential for membrane biogenesis, cell proliferation and differentiation. The role of cholesterol in cancer development and the regulation of cholesterol synthesis are still under active investigation. Here we show that under normal-sterol conditions，p53 directly represses the expres...
ORGANISM(S): Mus musculus 
2021-07-18 | GSE176112 | GEO
UnknownSQLE facilitates the pancreatic cancer progression via the lncRNA-TTN-AS1/miR-133b/SQLE axis.
Not available
S-EPMC9258714 | biostudies-literature
TranscriptomicsRNA sequencing to determine gene expression changes in SQLE knockdown osteosarcoma cells
In our study, we found that SQLE was critical to osteosarcoma progression. To identify the mechanism of SQLE in osteosarcoma, we conducted the RNA-seq analysis of SQLE knockdown in osteosarcoma cell line U2OS cells.
ORGANISM(S): Homo sapiens 
2024-12-16 | GSE245562 | GEO
UnknownThe interaction between polyphyllin I and SQLE protein induces hepatotoxicity through SREBP-2/HMGCR/SQLE/LSS pathway.
Not available
S-EPMC9937801 | biostudies-literature
TranscriptomicsExpression data from human Bladder cancer cell line J82 with control or overexpression of SQLE
Several reports showed that SQLE was upregulated in some types of cancer, and it is essential for cancer development. Herein, to uncover the role of SQLE in BCa, we performed the RNA-seq to detect the gene expression levels in BCa cell line J82 with overexpression of SQLE.
ORGANISM(S): Homo sapiens 
2024-04-28 | GSE231045 | GEO
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