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ProteomicsDoa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE
Transmembrane E3 ligases play crucial roles in homeostasis. Much protein and organelle quality control, and metabolic regulation, are determined by ER-resident MARCH6 E3 ligases, including Doa10 in yeast. Here, we present Doa10/MARCH6 structural analysis by cryo-EM and AlphaFold predictions, and a s...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD047499 | Pride
Ubiquitylation E3 ubiquitin ligases March6 Membrane proteins Doa10 Cryo-em Sqle 
ProteomicsProtein quality control by MARCH6/TRC8
Forward genetic screens in human cells we find that the proteasome-mediated degradation of the soluble misfolded reporter, mCherry-CL1, involves two ER-resident E3 ligases, MARCH6 and TRC8. To identify a more physiological correlate we used quantitative mass spectrometry and found that TRC8 and MARC...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008955 | Pride
Erad March6 Intramembrane proteolysis Trc8 Protein quality control 
UnknownMARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2.
Not available
S-EPMC8285810 | biostudies-literature
UnknownCholesterol increases protein levels of the E3 ligase MARCH6 and thereby stimulates protein degradation.
Not available
S-EPMC6378986 | biostudies-literature
UnknownMARCH6 suppresses Tembusu virus replication by targeting viral NS5 protein for TOLLIP-mediated selective autophagic degradation.
Not available
S-EPMC12282148 | biostudies-literature
UnknownDoa10/MARCH6 architecture interconnects E3 ligase activity with lipid-binding transmembrane channel to regulate SQLE.
Not available
S-EPMC10776854 | biostudies-literature
UnknownA MARCH6 and IDOL E3 Ubiquitin Ligase Circuit Uncouples Cholesterol Synthesis from Lipoprotein Uptake in Hepatocytes.
Not available
S-EPMC4719299 | biostudies-literature
UnknownMARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Not available
S-EPMC5934766 | biostudies-literature
UnknownThe E3 ubiquitin ligase MARCH6 degrades squalene monooxygenase and affects 3-hydroxy-3-methyl-glutaryl coenzyme A reductase and the cholesterol synthesis pathway.
Not available
S-EPMC3993563 | biostudies-literature
UnknownCoordinate regulation of mutant NPC1 degradation by selective ER autophagy and MARCH6-dependent ERAD.
Not available
S-EPMC6131187 | biostudies-literature
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