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ProteomicsProtein quality control by MARCH6/TRC8
Forward genetic screens in human cells we find that the proteasome-mediated degradation of the soluble misfolded reporter, mCherry-CL1, involves two ER-resident E3 ligases, MARCH6 and TRC8. To identify a more physiological correlate we used quantitative mass spectrometry and found that TRC8 and MARC...
ORGANISM(S): Homo sapiens (Human) 
2018-04-18 | PXD008955 | Pride
Erad March6 Intramembrane proteolysis Trc8 Protein quality control 
UnknownThe TRC8 ubiquitin ligase is sterol regulated and interacts with lipid and protein biosynthetic pathways.
Not available
S-EPMC3086825 | biostudies-literature
UnknownMARCH6 and TRC8 facilitate the quality control of cytosolic and tail-anchored proteins.
Not available
S-EPMC5934766 | biostudies-literature
UnknownThe hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.
Not available
S-EPMC21380 | biostudies-literature
UnknownTRC8-dependent degradation of hepatitis C virus immature core protein regulates viral propagation and pathogenesis.
Not available
S-EPMC4857398 | biostudies-literature
UnknownThe sterol-sensing endoplasmic reticulum (ER) membrane protein TRC8 hampers ER to Golgi transport of sterol regulatory element-binding protein-2 (SREBP-2)/SREBP cleavage-activated protein and reduces SREBP-2 cleavage.
Not available
S-EPMC2781446 | biostudies-literature
ProteomicsHCMV US2 co-opts TRC8 to degrade the ER-resident protein LMAN2L
The human cytomegalovirus (HCMV) pUS2 glycoprotein exploits the host’s endoplasmic reticulum (ER)-associated degradation (ERAD) pathway to degrade MHC class I and prevent antigen presentation. Beyond MHC class I, pUS2 has been shown to target a range of cellular proteins for degradation, preventing ...
ORGANISM(S): Homo sapiens (Human) 
2024-06-23 | PXD050878 | Pride
Cytomegalovirus Proteomics Protein trafficking Protein degradation Plasma membrane 
UnknownHCMV US2 co-opts TRC8 to degrade the endoplasmic reticulum-resident protein LMAN2L.
Not available
S-EPMC11083459 | biostudies-literature
UnknownPlasma membrane profiling defines an expanded class of cell surface proteins selectively targeted for degradation by HCMV US2 in cooperation with UL141.
Not available
S-EPMC4397069 | biostudies-literature
ProteomicsA Quantitative Assessment of Arsenite-induced Perturnation of Ubiquitinated Proteome
Arsenic contamination in food and ground water constitutes a public health concern to more than 100 million people worldwide. Individuals chronically exposed to arsenic through drinking and ingestion exhibit a higher risk in developing cancers and cardiovascular diseases. Nevertheless, the underlyin...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD035401 | Pride
Arsneite exposure Ubiquitome Human cells Data dependent acuisition Immunocapture Silac lableing Lc-ms/ms 
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