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ProteomicsTetraspanin-based immunocapture for high-depth proteomic profiling of extracellular vesicles from cerebrospinal fluid for biomarker discovery
Due to its proximity to cells of the central nervous system, cerebrospinal fluid (CSF) is an important source of novel biomarkers for neurological diseases. Membrane-bound extracellular vesicles (EVs) are enriched for proteins of intracellular and membrane origin, implicated in the pathogenesis of s...
ORGANISM(S): Homo sapiens (Human) 
2026-02-23 | PXD061653 | Pride
Cerebrospinal fluid Proteomics Tetraspanin Extracellular vesicle Immunocapture. 
ProteomicsMonitoring mAb proteoforms in mouse plasma using an automated immunocapture combined with top-down and middle-down mass spectrometry
We propose here a workflow based on an automated immunocapture followed by top-down and middle-down LC-MS/MS approaches to characterize mAb proteoforms spiked in mouse plasma. We demonstrate the applicability of our workflow on a large concentration range using pembrolizumab as a model. We also comp...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-08-27 | PXD040896 | Pride
Immunocapture Monoclonal antibody Proteoforms Middle-down mass spectrometry Top-down mass spectrometry 
ProteomicsProteomic profiling of KIT-containing EVs secreted by neoplastic human mast cells (SUB2)
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells. Despite potential contributions to diseases, KIT-co...
ORGANISM(S): Homo sapiens (Human) 
2025-12-02 | PXD033890 | Pride
Exosomes Microvesicles Extracellular vesicles Kit Immunocapture Mast cell 
ProteomicsProteomic profiling of KIT-containing EVs secreted by neoplastic human mast cells (SUB1)
Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells. Despite potential contributions to diseases, KIT-co...
ORGANISM(S): Homo sapiens (Human) 
2023-03-10 | PXD033889 | Pride
Exosomes Microvesicles Extracellular vesicles Kit Immunocapture Mast cell 
UnknownEffects of sample matrix in the measurement of antithrombin by LC-MS: A role for immunocapture.
Not available
S-EPMC9860377 | biostudies-literature
UnknownElectrodeposited magnetic nanoporous membrane for high-yield and high-throughput immunocapture of extracellular vesicles and lipoproteins.
Not available
S-EPMC9741596 | biostudies-literature
UnknownSelective immunocapture reveals neoplastic human mast cells secrete distinct microvesicle- and exosome-like populations of KIT-containing extracellular vesicles.
Not available
S-EPMC9838129 | biostudies-literature
UnknownFluorometric immunocapture assay for the specific measurement of matrix metalloproteinase-9 activity in biological samples: application to brain and plasma from rats with ischemic stroke.
Not available
S-EPMC3620676 | biostudies-literature
UnknownImmunocapture-Selected Reaction Monitoring Screening Facilitates the Development of ELISA for the Measurement of Native TEX101 in Biological Fluids.
Not available
S-EPMC4458717 | biostudies-literature
UnknownImmunocapture of virions with virus-specific antibodies prior to high-throughput sequencing effectively enriches for virus-specific sequences.
Not available
S-EPMC6542260 | biostudies-literature
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