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TranscriptomicsTranscription profiling of NIH3T3 cells treated with platelet-derived growth factor and Src kinase inhibitors to identify immediate early genes that are induced by PDGF through Src family kinases and other kinases.
This experiment was performed to identify immediate early genes that were induced by PDGF specifically through Src family kinases (SFKs), MEK1/2, or PI 3-K.
ORGANISM(S): Mus musculus 
2007-09-22 | E-GEOD-2196 | biostudies-arrayexpress
ProteomicsATP-site inhibitors induce unique conformations of the Src-family kinase, Fgr
Src family kinases are often overexpressed and constitutively active in cancer cells, where they represent promising targets for therapeutic intervention. In myeloid hematopoietic cells, Hck, Lyn, and Fgr are associated with both chronic and acute forms of myeloid leukemia. All three of these kinase...
ORGANISM(S): Homo sapiens (Human) 
2022-09-22 | PXD032014 | Pride
Src-family kinase  acute myeloid leukemia  hdx ms  hydrogen/deuterium exchange mass spectrometry 
ProteomicsAn SH3-binding allosteric modulator stabilizes the global conformation of the AML-associated Src-family kinase, Hck
While ATP-site inhibitors for protein-tyrosine kinases are often effective drugs, their clinical utility can be limited by off-target activity and acquired resistance mutations due to the conserved nature of the ATP-binding site. However, combining ATP-site and allosteric kinase inhibitors can overc...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD054878 | Pride
Hck  hdx-ms  hydrogen/deuterium exchange mass spectrometry  allosteric modulator  global conformation 
TranscriptomicsUnexpected Role for the B cell-specific Src Family Kinase Blk in the Development of IL-17-Producing gamma/delta T Cells
The Ag receptors on alpha/beta and gamma/delta T cells differ not only in the nature of the ligands that they recognize but also in their signaling potential. We hypothesized that the differences in alpha/beta - and gamma/delta TCR signal transduction were due to differences in the intracellular sig...
ORGANISM(S): Mus musculus 
2010-09-23 | E-GEOD-24281 | biostudies-arrayexpress
ProteomicsTyrosine Phosphorylation of NLRP3 by Src Family Protein Tyrosine Kinase Lyn Suppresses NLRP3 Inflammasome Activation
The NLRP3 inflammasome is a multi-protein complex that triggers the activation of the inflammatory protein caspase-1 and the maturation of the cytokine IL-1 in response to microbes and other danger signals in host cells. Here, we sought a deeper understanding of how the NLRP3 inflammasome is regulat...
ORGANISM(S): Mus musculus (Mouse) 
2022-05-19 | PXD028582 | Pride
Lyn tryosine kinase Murine nlrp3 inflammasome 
TranscriptomicsLKB1/STK11 Inactivation Leads to Expansion of Pro-Metastatic Tumor Sub-Population in Melanoma
Germline mutations in LKB1 (STK11) are associated with the Peutz–Jeghers syndrome (PJS), which includes aberrant mucocutaneous pigmentation, and somatic LKB1 mutations occur in 10% of cutaneous melanoma. By somatically inactivating Lkb1 with K-Ras activation (+/- p53 loss) in murine melanocytes, we ...
ORGANISM(S): Mus musculus 
2012-06-24 | E-GEOD-34866 | biostudies-arrayexpress
TranscriptomicsSRC1 gene regulation in endocrine resistant breast cancer cells
The development of breast cancer resistance to endocrine therapy results from an increase in cellular plasticity leading to the development of a steroid independent tumour. The p160 steroid coactivator protein SRC-1, through interactions with developmental proteins and other non-steroidal transcrip...
ORGANISM(S): Homo sapiens 
2012-01-11 | E-GEOD-28645 | biostudies-arrayexpress
ProteomicsEarly Signaling Dynamics of EGFR
Despite extensive study of the epidermal growth factor receptor (EGFR) signaling network, the immediate post-translational changes that occur in response to growth factor stimulation remain poorly characterized; as a result, the biological mechanisms underlying signaling initiation remain obscured. ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080800 | MassIVE
UnknownSrc-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells.
Not available
S-EPMC4252886 | biostudies-literature
ProteomicsUnique-region phosphorylation targets LynA for rapid degradation, tuning its expression and signaling in myeloid cells
The activity of Src-family kinases (SFKs), which phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs), is a critical factor regulating myeloid-cell activation. In a previous paper (Freedman et al., 2015) we showed that the SFK LynA is uniquely susceptible to rapid ubiquitin-mediated...
ORGANISM(S): Mus Musculus 
2019-07-15 | PXD014621 | panorama
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