This dataset comprises label-free quantitative proteomics of the secretome from human THP-1 serglycin (SRGN) knock-out and wild-type macrophage-like cells differentiated with PMA (M0) and polarized to M1 (LPS + IFN-γ) or M2 (IL-4 + IL-13). The study investigates how macrophage activation states in t...
Gfpt1, the rate limiting enzyme of the hexosamine biosynthetic pathway (HBP), provides the UDP-GlcNAc required for protein glycosylation. Biallelic mutations in GFPT1 cause congenital myasthenic syndromes (GFPT1-CMS), yet the molecular mechanisms linking impaired glycosylation to skeletal muscle dys...
