Sort   by:  
 Page size 
ProteomicsSystematic investigation of protein phosphorylation in biomolecular condensates
We have adapted a recently developed quantitative proteomics based approach to measure protein solubility following a lysate centrifugation assay to determine the proportion of a protein in distinct subpopulations in a proteome-wide manner (Sridharan et al., 2019). Further, by combining the solubili...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD027769 | Pride
Protein solubility Phosphorylation Biomolecular condensate 
ProteomicsProteome wide solubility profiling of Nucleozin treated A549 cells infected with Influenza-A
A549 WT and Rab11 deleted cell lines were infected with influenza-A and treated with nucleozin. We have evaluated the effect of an antiviral drug, nucleozin, on protein solubility at 13 hpi with influenza-A virus.
ORGANISM(S): Homo sapiens (Human) 
2023-04-23 | PXD041748 | Pride
Antiviral Phase transition Infection. lc-ms-ms 
ProteomicsCondensate-mediated molecular switch promotes viral replication under stress
We measured the abundance and solubility changes in MUmps and Human proteome during cellular stress in a chronic infection model.
ORGANISM(S): Mumps virus strain Enders Homo sapiens (Human) 
2023-04-26 | PXD026799 | Pride
Protein solubility Cellular strress Mumps Quantitative proteomics 
ProteomicsThe small molecule lipoamide modulates stress granule condensation with beneficial outcomes for familial amyotrophic lateral sclerosis models
We have evaluate the in-situ targets of lipoamide - a compund that causes alteration of the fluidity of in-vito FUS condensate and dissolves stress granules in cells - in Hela cells stressed with 1 mM arsenate. We have used quantitative proteomics based thermal proteome profiling to characterise the...
ORGANISM(S): Homo sapiens (Human) 
2025-05-09 | PXD039501 | Pride
Target engagement Thermal proteome profiling Als Biomolecular condensates Lipoamide 
Sort   by:  
 Page size