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TranscriptomicsGenome-wide DNA methylation analysis of lung carcinoma : Gene expression data
Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. Experimental Design Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on ...
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-60644 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation and expression analysis of lung carcinoma
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-60645 | biostudies-arrayexpress
TranscriptomicsLandscape of somatic allelic imbalances and copy number alterations in human lung carcinoma
Lung cancer is the worldwide leading cause of death from cancer. This GEO series correspond to one of the BAC aCGH data sets used as validation cohort for the study: Landscape of somatic allelic imbalances and copy number alterations in human lung cancer, Int J Cancer 2012. Genomic profiling of 78 l...
ORGANISM(S): Homo sapiens 
2012-10-09 | E-GEOD-29065 | biostudies-arrayexpress
TranscriptomicsNon-coding antisense transcription detected by conventional and single-stranded cDNA microarray
Recent bioinformatic studies revealed that many mammalian protein-coding genes also transcribe their complementary strands. This phenomenon raises questions regarding the validity of data obtained from double-stranded cDNA microarrays since hybridization to both strands may occur. To analyze experim...
ORGANISM(S): Homo sapiens 
2007-09-01 | E-GEOD-7860 | biostudies-arrayexpress
TranscriptomicsNormalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aberrations such as loss-of-heterozygosity (LOH). Methods developed for normalization of WGG arrays have mostly focused on diploid, norma...
ORGANISM(S): Homo sapiens 
2008-10-04 | E-GEOD-11977 | biostudies-arrayexpress
TranscriptomicsMolecular subtypes of breast cancer are associated with characteristic DNA methylation patterns
Introduction: Five different molecular subtypes of breast cancer have been identified through gene expression profiling. Each subtype has a characteristic expression pattern suggested to partly depend on cellular origin. We aimed to investigate whether the molecular subtypes also display distinct me...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-22210 | biostudies-arrayexpress
TranscriptomicsCharacterization of amplification patterns and target genes at chromosome 11q13 in CCND1-amplified sporadic and familial breast tumors
Amplification of chromosomal region 11q13, containing the cell cycle regulatory gene CCND1, is frequently found in breast cancer and other malignancies. It is associated with the favourable oestrogen receptor (ER) positive breast tumour phenotype, but also with poor prognosis and treatment failure. ...
ORGANISM(S): Homo sapiens 
2011-11-23 | E-GEOD-32578 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of lung carcinoma
Lung cancer is the worldwide leading cause of death from cancer. DNA methylation in gene promoter regions is a major mechanism of gene expression regulation that may promote tumorigenesis. However, whether clinically relevant subgroups based on DNA methylation patterns exist in lung cancer is not we...
ORGANISM(S): Homo sapiens 
2014-10-05 | E-GEOD-56044 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of breast cancer
Aberrant DNA methylation is frequently observed in breast cancer. However, the relationship between methylation patterns and the heterogeneity of breast cancer has not been comprehensively characterized. Whole-genome DNA methylation analysis using 450K Illumina BeadArrays was performed on 188 hum...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-75067 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation analysis of different cell types
We performed whole-genome methylation analysis using 450K Illumina BeadArrays on different human cell types. In total 24 experiments were performed. Dermal fibroblasts, three different epidermal melanocytes (dark, medium and light pigmentation), epidermal keratinocytes, mammary fibroblasts, mammary ...
ORGANISM(S): Homo sapiens 
2016-02-29 | E-GEOD-74877 | biostudies-arrayexpress
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