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TranscriptomicsAberrant silencing of imprinted genes on chromosome 12qF1 in mouse induced pluripotent stem cells
This SuperSeries is composed of the following subset Series: GSE20572: mRNA profiling of genetically matched ESCs and iPSCs GSE20575: mRNA profiling of iPSCs and derivative NT-ESCs Refer to individual Series
ORGANISM(S): Mus musculus 
2010-04-27 | E-GEOD-20576 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of genetically matched ESCs and iPSCs
Induced pluripotent stem cells (iPSCs) can be generated by enforced expression of defined transcription factors in somatic cells. It remains controversial whether iPSCs are equivalent to blastocyst-derived embryonic stem cells (ESCs). Using genetically matched cells, we found that the overall mRNA ...
ORGANISM(S): Mus musculus 
2010-04-28 | E-GEOD-20572 | biostudies-arrayexpress
TranscriptomicsmRNA profiling of iPSCs and derivative NT-ESCs
Pluripotent cells can be derived from somatic cells by either overexpression of defined transcription factors (resulting in induced pluripotent stem cells (iPSCs)) or by nuclear transfer or cloning (resulting in NT-ESCs). To determine whether cloning further reprograms iPSCs, we used iPSCs as donor ...
ORGANISM(S): Mus musculus 
2010-05-27 | E-GEOD-20575 | biostudies-arrayexpress
TranscriptomicsCNV analysis of iPS cell lines and H2A.X knockout ES cell
It is well-known that embryonic stem cells (ESC) are much more sensitive to replication-induced stress than differentiated cells but the underpinning mechanisms are largely unknown. H2A.X, a minor variant of H2A, constitutes only 1-10% of the mammalian genome. H2A.X plays a well-known for role in t...
ORGANISM(S): Mus musculus 
2014-09-07 | E-GEOD-42266 | biostudies-arrayexpress
TranscriptomicsAll-iPS cell mice generated from terminally differentiated B cells
The generation of induced pluripotent stem cells (iPSCs) often results in aberrant silencing of the imprinted Dlk1-Dio3 gene cluster, which compromises their ability to generate entirely iPSC-derived mice (“all-iPSC mice”). Here, we show that reprogramming in the presence of ascorbic acid attenu...
ORGANISM(S): Mus musculus 
2012-02-01 | E-GEOD-34761 | biostudies-arrayexpress
TranscriptomicsEarly passage mouse induced pluripotent stem (iPS) cells derivated from various somatic cell origins
Induced pluripotent stem (iPS) cells have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPS cells generated from different cell types are molecularly and functionally similar. Here, we show that iPS cells obtained from fi...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-22908 | biostudies-arrayexpress
GenomicsDefining a molecular roadmap of cellular reprogramming into iPS cells [ChIP-Seq]
Factor induced reprogramming is a slow and inefficient process with only rare cells progressing towards induced pluripotent stem cells (iPSCs). Owing to these restraints, mechanistic studies have been limited to analyses of heterogeneous bulk populations undergoing reprogramming and partially reprog...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-42477 | biostudies-arrayexpress
TranscriptomicsDefining a molecular roadmap of cellular reprogramming into iPS cells [miRNA profiling]
Factor induced reprogramming is a slow and inefficient process with only rare cells progressing towards induced pluripotent stem cells (iPSCs). Owing to these restraints, mechanistic studies have been limited to analyses of heterogeneous bulk populations undergoing reprogramming and partially reprog...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-42475 | biostudies-arrayexpress
TranscriptomicsDefining a molecular roadmap of cellular reprogramming into iPS cells [mRNA profiling]
Factor induced reprogramming is a slow and inefficient process with only rare cells progressing towards induced pluripotent stem cells (iPSCs). Owing to these restraints, mechanistic studies have been limited to analyses of heterogeneous bulk populations undergoing reprogramming and partially reprog...
ORGANISM(S): Mus musculus 
2012-12-20 | E-GEOD-42379 | biostudies-arrayexpress
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