Early passage mouse induced pluripotent stem (iPS) cells derivated from various somatic cell origins

ABSTRACT: Induced pluripotent stem (iPS) cells have been derived from various somatic cell populations through ectopic expression of defined factors. It remains unclear whether iPS cells generated from different cell types are molecularly and functionally similar. Here, we show that iPS cells obtained from fibroblasts, hematopoietic and myogenic cells exhibit distinct transcriptional and epigenetic patterns. Moreover, we demonstrate that cellular origin influences the in vitro differentiation potentials of iPS cells into embryoid bodies and different hematopoietic cells. Our results suggest that low-passage iPS cells retain a transient epigenetic memory of their somatic cells of origin, which manifests as differential gene expression and altered differentiation capacity. These observations might aff

ORGANISM(S): Mus musculus

SUBMITTER: Toshi Shioda 

PROVIDER: E-GEOD-22908 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress