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ProteomicsStereo-random Oligonucleotides Enable Efficient Recruitment of ADAR in vitro and in vivo
We used our previously published isASO-ID protocol to identify binders for two different adenosine deaminases acting on RNA- (ADAR-) recruiting antisense oligonucleotides (ONs). The ONs differed in their phosphorothioate content and their RNA editing potency and efficiency through the recruitment of...
ORGANISM(S): Homo sapiens (Human) 
2025-07-31 | PXD066763 | Pride
Antisense oligonucleotide Basu Drug protein interactome Rna editing Proximity biotinylation Biotin ligase Silac In situ biotinylation Adar-recruiting oligonucleotides 
ProteomicsProfiling the interactome of oligonucleotide drugs by proximity biotinylation
Drug-ID applies proximity biotinylation to identify drug-protein interactions inside living cells. The covalent conjugation of a drug molecule with a biotin ligase enables targeted biotinylation of the drug-bound proteome and its identification by SILAC-MS/MS. We investigate the interactome of two w...
ORGANISM(S): Homo sapiens (Human) 
2024-01-09 | PXD045992 | Pride
Antisense oligonucleotide Basu Proximity biotinylation Drug protein interactome Live cell Biotin ligase Hdac inhibitors Silac In situ biotinylation Bet inhibitors Bioid 
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