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MetabolomicsA novel targeted/untargeted GC-Orbitrap metabolomics methodology applied to Candida albicans and Staphylococcus aureus biofilms

INTRODUCTION: Combined infections from Candida albicans and Staphylococcus aureus are a leading cause of death in the developed world. Evidence suggests that Candida enhances the virulence of Staphylococcus - hyphae penetrate through tissue bar...

2017-02-20 | MTBLS370 | MetaboLights
MetabolomicsCitrate serves as a signal molecule to modulate carbon metabolism and iron homeostasis in Staphylococcus aureus

Pathogenic bacteria's metabolic adaptation for survival and proliferation within hosts is a crucial aspect of bacterial pathogenesis. Here, we demonstrate that citrate, the first intermediate of the tricarboxylic acid (TCA) cycle, plays a key role as a regulator of gene expression in Staphylococc...

2024-04-26 | MTBLS4276 | MetaboLights
TranscriptomicsStp1 and Stk1 regulated genes during S. aureus post-exponential phase growth
Genes that showed altered expression in Stk1 and Stp1 deficient Staphylococcus aureus Newman were identified. strain comparison, global regulation Deletion mutants were examined for alterations in gene expression.
ORGANISM(S): Staphylococcus aureus 
2010-04-22 | E-GEOD-21426 | biostudies-arrayexpress
TranscriptomicsM-OM-^CB-dependent yabJ-spoVG operon involved in regulation of extracellular nuclease, lipase and protease expression in Staphylococcus aureus
The alternative sigma factor M-OM-^CB of Staphylococcus aureus is involved in the coordination of the general stress response, expression of virulence determinants and modulation of antibiotic resistance levels. It controls a large regulon, either directly by recognizing conserved M-OM-^CB promoter ...
ORGANISM(S): Staphylococcus aureus 
2011-11-23 | E-GEOD-30115 | biostudies-arrayexpress
TranscriptomicsTranscriptome of the NWMN_0641 deletion mutant strain and the wild-type Staphylococcus aureus Newman strain
To study the roles of NWMN_0641, we used microarray to compare the transcriptome of the NWMN_0641 deletion strain with that of the wild-type Staphylococcus aureus Newman strain. Transcriptome of the NWMN_0641 deletion mutant strain and the wild-type Newman strain We sought to obtain the transcriptom...
ORGANISM(S): Staphylococcus aureus subsp. aureus str. Newman 
2014-11-04 | E-GEOD-57260 | biostudies-arrayexpress
GenomicsStaphylococcus aureus strain:Newman
Staphylococcus aureus strain:Newman Transcriptome or Gene expression
PRJNA1503662 | ENA
GenomicsStaphylococcus aureus subsp. aureus str. Newman
Staphylococcus aureus subsp. aureus str. Newman Genome sequencing
PRJNA1224739 | ENA
TranscriptomicsA novel aCGH method for non-model organisms for assessing genomes and de-novo transcriptome sequencing reads (Staphylococcus aureus)
Genomes and transcriptomes of non-model organisms can be analyzed using next-generation sequencing technologies, but de-novo sequencing and annotating a full eukaryotic genome is still challenging. So, -omics experimentation with non-model organisms requires a suite of technologies to obtain reliabl...
ORGANISM(S): Staphylococcus aureus 
2014-05-19 | E-GEOD-51148 | biostudies-arrayexpress
TranscriptomicsSRD: a Staphylococcus Regulatory RNA Database
We report the use of Next Generation RNA Sequencing for confirming or improving initial identification of small regulatory RNA in Staphylococcus aureus to prodive a list of the most probable RNA molecules transcribed as independent units. Extraction of RNAs in exponential phase of growth in Newman a...
ORGANISM(S): Staphylococcus aureus 
2015-03-01 | E-GEOD-64026 | biostudies-arrayexpress
TranscriptomicsCodY in Staphylococcus aureus: regulatory link between metabolism and virulence gene expression
CodY is a conserved regulator in gram-positive organisms described to repress metabolic genes mainly involved in nitrogen metabolism but also to control the expression of virulence genes in pathogens. We constructed codY gene-replacement mutants in three unrelated S. aureus strains (Newman, UAMS-1, ...
ORGANISM(S): Staphylococcus aureus subsp. aureus USA300 
2008-11-06 | E-GEOD-12340 | biostudies-arrayexpress
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