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GenomicsGenome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, r...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17850 | biostudies-arrayexpress
ProteomicsIdentification of novel STAT6-regulated proteins in mouse B cells by comparative transcriptome and proteome analysis
IL-4/STAT6-regulated transcriptome and proteome were compared in primary B cells isolated from wild-type and STAT6-deficient mice. B cells were purified from the spleen and stimulated in vitro with anti-CD40 and LPS or anti-IgM-F(ab)2 in the presence or absence of IL-4. Transcriptome analysis was pe...
ORGANISM(S): Mus musculus (Mouse) 
2017-03-06 | PXD005224 | Pride
Stat6 Label-free quantitative mass spectrometry B cells Il-4 
TranscriptomicsActivation of STAT6 by STING Is Critical for Antiviral Innate Immunity
Analysis of the transcriptional response of HEK293 or HEK293-STAT6 stable cell lines to poly(I:C) transfection. The hypothesis tested was that poly(I:C) transfection is capable of inducing the expression of STAT6-dependent antiviral genes. mRNA isolated from HEK293 or HEK293-STAT6 stable cell lines ...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26435 | biostudies-arrayexpress
GenomicNAB2-STAT6 Gene Fusions in Solitary Fibrous Tumor by Integrative Sequencing

Transcriptome sequencing of solitary fibrous tumors / hemangiopericytomas from a variety of anatomic sites revealed recurrent gene fusions between two genes, NAB2 and STAT6. All SFTs examined exhibited an in-frame fusion transcript encoding a fusion protein containing the EGR1 interaction domain ...

phs000567 | dbGaP
TranscriptomicsExpression Data from BALB/c and Stat6-deficient bone marrow derived macrophages (BMDM)
We used microarrays to find Stat6 dependent genes in control and IL-4 exposed bone marrow derived macrophages. Alternatively activated macrophages (AAM) accumulate in tissues during Th2-associated immune responses like helminth infections and allergic disorders. These cells possess potent inhibitor...
ORGANISM(S): Mus musculus 
2010-07-19 | E-GEOD-20030 | biostudies-arrayexpress
TranscriptomicsPPARg and IL-4-induced gene expression data from wild-type and STAT6 knockout mouse bone marrow-derived macrophages
C57Bl/6 wild-type and STAT6 KO mice were used to study PPARg and IL-4 signaling. Bone marrow of 3 mice per group was isolated and differentiated to macrophages with M-CSF (20 ng/ml). 20 ng/ml IL-4 was used to induce alternative macrophage activation and 1 uM Rosiglitazone (RSG) was used to activate ...
ORGANISM(S): Mus musculus 
2010-11-18 | E-GEOD-25088 | biostudies-arrayexpress
GenomicsDiscrete Roles of STAT4 and STAT6 Transcription Factors in Tuning Epigenetic Modifications and Transcription during Helper T Cell Differentiation (ChIP-Seq)
Signal transducer and activator of transcription 4 (STAT4) and STAT6 are key factors in the specification of helper T cells; however, their direct roles in driving differentiation are not well understood. Using chromatin immunoprecipitation and massive parallel sequencing, we quantitated the full c...
ORGANISM(S): Mus musculus 
2010-06-18 | E-GEOD-22104 | biostudies-arrayexpress
GenomicsSTAT6 and skin microbiome
STAT6 and skin microbiome
PRJEB104316 | ENA
TranscriptomicsGene array for identifying molecules involved in IL-10 regulation during Th17 polarization
IL-10 production by Th17 cells is critical for limiting autoimmunity and inflammatory responses. Gene array analysis on Stat6 and T-bet double deficient Th17 cells identified the Th2 transcription factor c-Maf to be synergistically up-regulated by IL-6 plus TGFbeta, and associated with Th17 IL-10 pr...
ORGANISM(S): Mus musculus 
2009-03-03 | E-GEOD-15029 | biostudies-arrayexpress
GenomicsPhosphorylated-Ser807 STAT6 protects macrophages from senescence
Phosphorylated-Ser807 STAT6 protects macrophages from senescence
PRJNA1167306 | ENA
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