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MetabolomicsRapid metabolic shifts occur during the transition between hunger and satiety in Drosophila melanogaster
Metabolites are active controllers of cellular physiology, but their role in complex behaviors is less clear. Here we report the metabolic changes that occur during the transition between hunger and satiety in Drosophila melanogaster. To analyze these data in the context of fruit fly metabolic netwo...
2019-07-13 | MTBLS180 | MetaboLights
MetabolomicsSteady state isotope tracing in C. elegans (GC-MS analyses)

The metabolic network, composed of thousands of metabolic reactions, is essential for any organism. Despite its importance, a systems level understanding of how metabolic network is wired by reactions that carry flux in unperturbed condition and rewired by transcriptionally activating or repressi...

2024-12-03 | MTBLS11742 | MetaboLights
MetabolomicsSteady state isotope tracing in C. elegans (LC-MS analyses)

The metabolic network, composed of thousands of metabolic reactions, is essential for any organism. Despite its importance, a systems level understanding of how metabolic network is wired by reactions that carry flux in unperturbed condition and rewired by transcriptionally activating or repressi...

2024-12-03 | MTBLS11741 | MetaboLights
MetabolomicsThe transition from winter to spring has an impact on the airway metabolome profile of asthmatic horses

Equine asthma is a chronic, non-infectious inflammatory disease of the lower airways in horses, classified as mild to moderate (MEA) or severe (SEA). Its pathogenesis is not fully understood and is influenced by environmental and seasonal factors. In this cross-sectional study, seasonal effects o...

2026-03-23 | MTBLS13953 | MetaboLights
GenomicsPropagation of Adipogenic Signals through an Epigenomic Transition State
The transcriptional mechanisms by which temporary exposure to developmental signals instigates adipocyte differentiation are unknown. During early adipogenesis, we find transient enrichment of the glucocorticoid receptor (GR), CCAAT/enhancer binding protein b (CEBPb), p300, mediator subunit 1, and h...
ORGANISM(S): Mus musculus 
2010-05-20 | E-GEOD-21898 | biostudies-arrayexpress
TranscriptomicsA systematic analysis of the time series gene expression in TGF-beta induced EMT by Next-generation sequencing
The goal of this study is to characterize time course gene expression profiles during TGF-beta induced EMT. In particular, we aim to identify and characterize master transcription factors regulate the transition into partial-EMT state. A time series mRNA profile in A549 cells is generated from TGF-b...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-69667 | biostudies-arrayexpress
TranscriptomicsTransition of embryonic stem cells from ground state pluripotency
Mouse embryonic stem cells were maintained in minimal and chemically-defined culture conditions supporting naive pluripotency. Inhibitors of the Gsk3 (CHIR99021) and Mek/Erk (PD0325901) pathways were withdrawn, cultures maintained for 24 hours, and subsequently sorted by flow cytometry based on fluo...
ORGANISM(S): Mus musculus 
2017-02-22 | E-MTAB-5304 | biostudies-arrayexpress
TranscriptomicsTransition of embryonic stem cells from ground state pluripotency (RNA-seq)
Mouse embryonic stem cells were maintained in minimal and chemically-defined culture conditions supporting naive pluripotency. Inhibitors of the Gsk3 (CHIR99021) and Mek/Erk (PD0325901) pathways were withdrawn, cultures maintained for 24 hours, and subsequently sorted by flow cytometry based on fluo...
ORGANISM(S): Mus musculus 
2017-02-22 | E-MTAB-5305 | biostudies-arrayexpress
TranscriptomicsCell state transitions regulated by Slug are critical for tissue regeneration and tumor initiation [Agilent microarray samples]
Alterations that perturb differentiation and cell state transitions can lead to defects in development, function and the genesis of cancer. Studying cellular plasticity at high resolution and in real time has proven difficult using existing methods. Here, we use a quantitative approach to gain insig...
ORGANISM(S): Homo sapiens 
2014-06-23 | E-GEOD-54713 | biostudies-arrayexpress
GenomicsEpigenetic enhancer modifications determine the angiogenic to quiescent endothelial state transition
Epigenetic enhancer modifications determine the angiogenic to quiescent endothelial state transition
PRJNA1236325 | ENA
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