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MetabolomicsX chromosome dosage drives statin-induced dysglycemia and mitochondrial dysfunction

Statin drugs lower blood cholesterol levels for cardiovascular disease prevention. Women are more likely than men to experience adverse statin effects, particularly new-onset diabetes (NOD) and muscle weakness. Here we find that impaired glucose homeostasis and muscle weakness in statin-treated f...

2024-05-23 | MTBLS9677 | MetaboLights
MetabolomicsStatin Immuno-Metabolomics in Asthma (part V)
Not available
ORGANISM(S): Macaca mulatta 
ST000847 | MetabolomicsWorkbench
MetabolomicsStatin Immuno-Metabolomics in Asthma (part IV)
Not available
ORGANISM(S): Macaca mulatta 
ST000846 | MetabolomicsWorkbench
MetabolomicsStatin Immuno-Metabolomics in Asthma (part III)
Not available
ORGANISM(S): Macaca mulatta 
ST000845 | MetabolomicsWorkbench
MetabolomicsStatin Immuno-Metabolomics in Asthma (part II)
Not available
ORGANISM(S): Macaca mulatta 
ST000844 | MetabolomicsWorkbench
MetabolomicsStatin Immuno-Metabolomics in Asthma (part I)
Not available
ORGANISM(S): Macaca mulatta 
ST000843 | MetabolomicsWorkbench
MetabolomicsA metabolic dependency for host isoprenoids in the obligate intracellular pathogen Rickettsia parkeri underlies a sensitivity for the statin class of host-targeted therapeutics
Gram-negative bacteria in the order Rickettsiales are obligate intracellular parasites that cause human diseases such typhus and spotted fever. They have evolved a dependence on essential nutrients and metabolites from the host cell as a consequence of extensive genome streamlining. However, it rema...
2019-10-31 | MTBLS846 | MetaboLights
ProteomicsStatin therapy inhibits Fatty Acid Synthase via dynamic protein modifications
Recent discoveries revealed HMG-CoA is a reactive metabolite that can non-enzymatically modify proteins and impact their activity. Therefore, we predicted that inhibition of HMGCR by statins might increase HMG-CoA levels and protein modifications. Upon statin treatment, we observed a strong increase...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-05-20 | PXD030952 | Pride
Hmgylation Statin Fatty acid synthase 
TranscriptomicsStatin-induced transcriptional changes in breast cancer
Global gene expression profiling was performed on paired tumor biopsies collected before and after 2 weeks of statin treatment with the aim of detecting statin induced changes on tumoral gene expression. In this phase II clinical study using the “window-of-opportunity” design, in which the treatment...
ORGANISM(S): Homo sapiens 
2015-06-23 | E-GEOD-63427 | biostudies-arrayexpress
GenomicGenetic Susceptibility to Statin-Induced Myopathy

Severe myopathic events occur in 0.1-0.5% of patients taking statins. Although genetic association studies have identified some possibly associated gene loci, these have not been reproducible in additional studies with independent patient cohorts. A more reasonable explanation for susceptibility ...

phs001342 | dbGaP
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