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UnknownA chemical reporter facilitates the detection and identification of lysine HMGylation on histones.
Not available
S-EPMC6194501 | biostudies-literature
ProteomicsLeucine catabolic enzyme AUH regulates brown fat thermogenesis through HMGylation of PPARγ and RNA-binding function in male mice
A strong association between leucine and obesity has been well established; however, the role of leucine catabolic enzymes in adipose tissue remains largely unknown. Here, we show that knockdown of the leucine catabolic enzyme AU RNA binding methylglutaconyl-CoA hydratase (AUH) in brown adipocytes r...
ORGANISM(S): Mus Musculus 
2026-03-09 | PXD075390 |
ProteomicsA class of reactive acyl-CoA species reveals the nonenzymatic origins of protein acylation
The mechanisms underlying the formation of acyl protein modifications remain poorly understood. By investigating the reactivity of endogenous acyl-CoA metabolites, we found a class of acyl-CoAs that undergoes intramolecular catalysis to form reactive intermediates which non-enzymatically modify prot...
ORGANISM(S): Mus musculus (Mouse) 
2017-04-11 | PXD005895 | Pride
Glutarylation Hmgylation Nonenzymatic protein acylation 
UnknownurPTMdb/TeaProt: Upstream and Downstream Proteomics Analysis.
Not available
S-EPMC9904285 | biostudies-literature
ProteomicsStatin therapy inhibits Fatty Acid Synthase via dynamic protein modifications
Recent discoveries revealed HMG-CoA is a reactive metabolite that can non-enzymatically modify proteins and impact their activity. Therefore, we predicted that inhibition of HMGCR by statins might increase HMG-CoA levels and protein modifications. Upon statin treatment, we observed a strong increase...
ORGANISM(S): Homo sapiens (Human) Sus scrofa domesticus (domestic pig) 
2022-05-20 | PXD030952 | Pride
Hmgylation Statin Fatty acid synthase 
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