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ProteomicsDisease-linked lysine glutarylation impairs function and interactions of mitochondrial proteins and contribute to mitochondrial heterogeneity
Inherited deficiencies of the lysine and tryptophan catabolic pathways, due to mutations in the glutaryl-CoA-dehydrogenase (GCDH) gene, cause glutaric aciduria type 1 (GA1). In mammals two metabolic routes for L-lysine oxidation exist, the mitochondrial saccharopine pathway, which is predominant in ...
ORGANISM(S): Mus musculus (Mouse) 
2018-07-11 | PXD007881 | Pride
Metabolism Molecular biology of disease Protein interaction Glutaryl-coa-dehydrogenase Glutaryl-proteome Proteolysis & proteomics Post-translational modifications Glutamate dehydrogenase 
UnknownFunctions and Mechanisms of Lysine Glutarylation in Eukaryotes.
Not available
S-EPMC8264553 | biostudies-literature
UnknownComputational Identification of Lysine Glutarylation Sites Using Positive-Unlabeled Learning.
Not available
S-EPMC7521029 | biostudies-literature
GenomicsGlutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
Glutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
PRJNA545040 | ENA
UnknownProtTrans-Glutar: Incorporating Features From Pre-trained Transformer-Based Models for Predicting Glutarylation Sites.
Not available
S-EPMC9194472 | biostudies-literature
UnknownLysine glutarylation is a protein posttranslational modification regulated by SIRT5.
Not available
S-EPMC4108075 | biostudies-literature
UnknownDelayed Impact of 2-Oxoadipate Dehydrogenase Inhibition on the Rat Brain Metabolism Is Linked to Protein Glutarylation.
Not available
S-EPMC9198357 | biostudies-literature
UnknownMetabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation.
Not available
S-EPMC4563717 | biostudies-literature
TranscriptomicsGlutarylation of Histone H4 Lysine 91 Regulates Chromatin Dynamics
Chromatin is decorated with diverse histone posttranslational modifications (PTMs) that are involved in regulating chromatin structure and dynamics during various DNA-associated processes such as gene transcription, DNA replication and DNA damage repair. Here, we combine a chemical reporter with mas...
ORGANISM(S): Saccharomyces cerevisiae Homo sapiens 
2019-09-16 | GSE131807 | GEO
ProteomicsDeglutarylation of GCDH by SIRT5 controls lysine metabolism in mice
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be non-enzymatically driven by glutaryl-CoA. In mam...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-21 | PXD018156 | Pride
Gcdh Sirt5 Sirtuins Mitochondria Acylation 
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