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MetabolomicsSIRT5 alleviate cardiomyocyte senescence in radiation-induced heart disease via desuccinylation of HADHB

SIRT5 deficiency caused widespread protein hypersuccinylation in cardiac tissue. Succinylation proteomic analysis revealed HADHB as the key SIRT5 target, with lysine 292 (K292) being the dominant succinylation site. Functional studies demonstrated that K292 succinylation impairs HADHB-mediated fa...

2026-03-15 | MTBLS14057 | MetaboLights
MetabolomicsMetabolomics analysis of Sirt5 knockdown (KD) melanoma
Not available
ORGANISM(S): Homo sapiens 
ST000698 | MetabolomicsWorkbench
MetabolomicsMetabolomics analysis of mouse liver with or without SIRT5 deficiency
Not available
ORGANISM(S): Mus musculus 
ST002152 | MetabolomicsWorkbench
ProteomicsSIRT5-mediated lysine desuccinylation regulates oxidative stress adaptation for intracellular infection of Magnaporthe oryzae
Plant-pathogenic fungi have developed kinds of detoxification strategies to suppress host reactive oxygen species (ROS) for colonization, but how this process is elaborately regulated has not been well revealed. Here we show that the SIRT5-mediated protein desuccinylation acts as a master regulator ...
ORGANISM(S): Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae) 
2024-03-06 | PXD044696 | Pride
De-succinylation oxidative stress sirt5 magnaporthe oryzae 
ProteomicsDeglutarylation of GCDH by SIRT5 controls lysine metabolism in mice
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be non-enzymatically driven by glutaryl-CoA. In mam...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-21 | PXD018156 | Pride
Gcdh Sirt5 Sirtuins Mitochondria Acylation 
GenomicsRNA-seq of SIRT5-KO cells infected with SARS-CoV-2
RNA-seq of SIRT5-KO cells infected with SARS-CoV-2
PRJNA778712 | ENA
GenomicsSIRT5 loss promotes hepatocarcinogenesis via bile acid-induced immunosuppressive microenvironment
SIRT5 loss promotes hepatocarcinogenesis via bile acid-induced immunosuppressive microenvironment
PRJNA795446 | ENA
GenomicsThe deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics.
The deacylase SIRT5 supports melanoma viability by regulating chromatin dynamics.
PRJNA715645 | ENA
ProteomicsSIRT5-Mediated FDX1 Desuccinylation Confers Cuproptosis Resistance in Lung cancer
Cuproptosis, a copper-dependent cell death process induced by excessive copper, represents an emerging therapeutic strategy in oncology. However, tumor specific molecular pathways regulating this process remain poorly defined. Here, we demonstrate that copper levels are elevated in lung adenocarcino...
ORGANISM(S): Homo Sapiens 
PXD077292 |
GenomicsRole of SIRT5 in Inhibition of Myocardial Hypertrophy
Role of SIRT5 in Inhibition of Myocardial Hypertrophy
PRJNA777232 | ENA
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