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ProteomicsDeglutarylation of GCDH by SIRT5 controls lysine metabolism in mice
A wide range of protein acyl modifications has been identified on enzymes across various metabolic processes; however, the impact of these modifications remains poorly understood. Protein glutarylation is a recently identified modification that can be non-enzymatically driven by glutaryl-CoA. In mam...
ORGANISM(S): Homo sapiens (Human) Escherichia coli 
2022-02-21 | PXD018156 | Pride
Gcdh Sirt5 Sirtuins Mitochondria Acylation 
GenomicsMelanoma Addiction to GCDH is Mediated by NRF2
Melanoma Addiction to GCDH is Mediated by NRF2
PRJNA824485 | ENA
TranscriptomicsMelanoma Addiction to GCDH is Mediated by NRF2
We identify melanoma addiction to the mitochondrial protein Glutaryl-CoA dehydrogenase (GCDH), which functions in lysine metabolism and controls protein glutarylation. GCDH knockdown promoted ATF4-ATF3 signaling and cell death programs in melanoma cells, an activity blocked by knockdown of the upstr...
ORGANISM(S): Homo sapiens 
2022-05-12 | GSE200424 | GEO
UnknownNRF2 mediates melanoma addiction to GCDH by modulating apoptotic signalling.
Not available
S-EPMC9977532 | biostudies-literature
UnknownTreatment of glutaric aciduria type I (GA-I) via intracerebroventricular delivery of GCDH.
Not available
S-EPMC11197790 | biostudies-literature
UnknownGCDH Acetylation Orchestrates DNA Damage Response and Autophagy via Mitochondrial ROS to Suppress Hepatocellular Carcinoma Progression.
Not available
S-EPMC12395558 | biostudies-literature
UnknownSystemic delivery of AAV-GCDH ameliorates HLD-induced phenotype in a glutaric aciduria type I mouse model.
Not available
S-EPMC11231595 | biostudies-literature
UnknownGlutaryl-CoA dehydrogenase (GCDH) enhances renal malignancy risk via modulating glutarylcarnitine levels.
Not available
S-EPMC12514084 | biostudies-literature
UnknownCompilation of Genotype and Phenotype Data in GCDH-LOVD for Variant Classification and Further Application.
Not available
S-EPMC10742628 | biostudies-literature
UnknownCrotonylation-related gene <i>GCDH</i> promotes osteoarthritis pathogenesis through flavin adenine dinucleotide signaling: mechanism exploration and experimental validation.
Not available
S-EPMC12815788 | biostudies-literature
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