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UnknownSirt5 improves cardiomyocytes fatty acid metabolism and ameliorates cardiac lipotoxicity in diabetic cardiomyopathy via CPT2 de-succinylation.
Not available
S-EPMC11091707 | biostudies-literature
ProteomicsSIRT5-mediated lysine desuccinylation regulates oxidative stress adaptation for intracellular infection of Magnaporthe oryzae
Plant-pathogenic fungi have developed kinds of detoxification strategies to suppress host reactive oxygen species (ROS) for colonization, but how this process is elaborately regulated has not been well revealed. Here we show that the SIRT5-mediated protein desuccinylation acts as a master regulator ...
ORGANISM(S): Magnaporthe oryzae (Rice blast fungus) (Pyricularia oryzae) 
2024-03-06 | PXD044696 | Pride
De-succinylation oxidative stress sirt5 magnaporthe oryzae 
UnknownIFN-α confers epigenetic regulation of HBV cccDNA minichromosome by modulating GCN5-mediated succinylation of histone H3K79 to clear HBV cccDNA.
Not available
S-EPMC7487718 | biostudies-literature
ProteomicsNovel high-resolution ion mobility mass spectrometry for site-specific quantification of the sirtuin-5 regulated kidney succinylome
Protein post-translational modifications (PTMs) dynamically regulate essential biological and cellular processes. Lysine succinylation changes the amino acid charge, potentially affecting protein structures and functions, and dysregulation of protein succinylation may lead to metabolic disorders. Pr...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-10-14 | MSV000099489 | MassIVE
ProteomicsSIRT5 ameliorates cardiac fibrosis via PCK2 de-succinylation–mediated metabolic reprogramming in cardiac fibroblasts
WT and Sirt5-/- CFBs were stimulated with TGF-β1 (10 ng/mL) for 36 hours. Cells were harvested, snap-frozen, and stored at -80℃. The experiment was independently repeated six times at different time points. Cells from each replicate were pooled to yield more than 3 mg of protein per group. Pooled WT...
ORGANISM(S): Mus Musculus 
2025-11-15 | PXD070811 |
UnknownNew Avenues of Heme Synthesis Regulation.
Not available
S-EPMC9267699 | biostudies-literature
ProteomicsPCK2-mediated PQBP1 lactylation promotes asthmatic inflammation through PRMT5 inhibition
Background: Asthma involves chronic inflammation linked to metabolic reprogramming, but how metabolites reshape epigenetics through post-translational modifications remains unclear. Methods: We used HDM-induced asthmatic mice with multi-omics analyses (metabolomics, PTM-proteomics, ChIP-seq) and val...
ORGANISM(S): Homo Sapiens 
2025-11-12 | PXD070618 |
ProteomicsLysine succinylation and acetylation in Pseudomonas aeruginosa
The present data set provides the first description of lysine succinylation and lysine acetylation in P. aeruginosa grown in 4 carbon sources using a two-dimensional immunoaffinity approach coupled with nanoliquid chromatography tandem mass spectrometry. A total of 1522 succinylated sites (612 prote...
ORGANISM(S): Pseudomonas aeruginosa (strain UCBPP-PA14) 
2018-05-21 | PXD008662 | Pride
Lysine acetylation Proteomics Lysine succinylation Bacteria Pseudomonas aeruginosa 
ProteomicsInvestigating the Succinylome and Malonylome of Schizophrenia
The succinylome and malonylome of human oligodendrocyte precursors (MO3.13 line) and postmortem brain tissue (whole lysates and mitochondrial enrichments) were studied with shotgun mass spectrometry. The goal was to determine what changes in oligodendrocytes are induced with the addition of the NMDA...
ORGANISM(S): Homo sapiens (Human) 
2022-10-13 | PXD014188 | Pride
Schizophrenia Malonylation Succinylation Mk-801 Antipsychotics 
GenomicsLoss of SIRT5 accelerates the development of pressure-overload induced heart failure upon dysregulating purine and pyrimidine metabolism
Loss of SIRT5 accelerates the development of pressure-overload induced heart failure upon dysregulating purine and pyrimidine metabolism
PRJNA1180940 | ENA
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