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ProteomicsA network of interacting ciliary tip proteins with opposing activities imparts slow and processive microtubule growth
Cilia are essential motile or sensory organelles found on many eukaryotic cells. Their formation and function rely on axonemal microtubules, which exhibit very slow dynamics, however the underlying biochemical mechanisms are largely unexplored. Here, we reconstituted in vitro the individual and coll...
ORGANISM(S): Homo sapiens (Human) 
2024-11-19 | PXD055631 | Pride
Mt dynamics Microtubles Ip-ms Cell biology 
ProteomicsDistinct (Phospho)proteomic Landscapes of PIK3CA Mutants Reveal Insulin-Mediated Reactivation of PI3K Pathway and Adaptive MAPK Signaling
Oncogenic mutations in p110α subunit of phosphatidylinositol-3-kinase (PI3K), primarily H1047R in the kinase domain and E545K in the helical domain, induce constitutive PI3K/AKT pathway activation, driving tumor progression. Isoform-specific inhibitors such as alpelisib have been developed, but thei...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD067648 | Pride
Proteomics  phosphoproteomics  pik3ca mutation 
ProteomicsSpore inoculum size impacts substrate degradation and sporulation but not the secretome during colonization of whole yellow pea (Pisum sativum) by Aspergillus oryzae
Aspergillus oryzae is used in solid-state fermentation (SSF) to produce plant-based foods. To this end, the substrate is inoculated with spores of this fungus. So far, the effect of inoculum size on SSF with A. oryzae has primarily focused on the production of specific enzymes. Therefore, the aim of...
ORGANISM(S): Pisum sativum (Garden pea) Aspergillus oryzae RIB40 
2026-06-26 | PXD070642 | Pride
Fungus Solid-state fermentation Plant-based meat alternative Aspergillus oryzae Pisum sativum Pea 
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