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GenomicsTDP-1, the C. elegans ortholog of TDP-43, limits the accumulation of double stranded RNA
C. elegans mutants deleted for TDP-1, an ortholog of the neurodegeneration-associated RNA binding protein TDP-43, display only mild phenotypes. Nevertheless, transcriptome sequencing revealed that many RNAs were altered in accumulation and/or processing in the mutant. Analysis of these transcription...
ORGANISM(S): Caenorhabditis elegans 
2014-11-19 | E-GEOD-61581 | biostudies-arrayexpress
TranscriptomicsGlucocorticoid-induced reversal of IL1b stumulated gene expression in OE-E6/7 cells
Studies indicate that high-grade serous ovarian carcinoma (HGSOC), the most common epithelial ovarian carcinoma histotype, originates from the fallopian tube epithelium (FTE). Risk factors for this cancer include reproductive parameters associated with lifetime ovulatory events. Ovulation is an ac...
ORGANISM(S): Homo sapiens 
2015-01-27 | E-GEOD-54608 | biostudies-arrayexpress
GenomicsA Cancer Cell-Line Titration Series for Evaluating Somatic Classification
Accurate detection of somatic single nucleotide variants and small insertions and deletions from DNA sequencing experiments of tumour-normal pairs is a challenging task. Tumour samples are often contaminated with normal cells confounding the available evidence for the somatic variants. Furthermore...
EGAS00001001016 | EGA
UnknownRepetitive transcranial magnetic stimulation for smoking cessation: a pivotal multicenter double-blind randomized controlled trial.
Not available
S-EPMC8429333 | biostudies-literature
GenomicsCell-line Mixing Experiment Verification Data - samples
Description not provided
EGAD00001001044 | EGA
GenomicsCell-line Mixing Experiment Sequencing Data - samples
Description not provided
EGAD00001001043 | EGA
TranscriptomicsTranscription profiling of C. elegans daf-19(+) and daf-19(-) mutants
By screening for genes possessing canonical X-box sequences in promoters of three Caenorhabditis species, namely C. elegans, C. briggsae and C. remanei, we identified 93 genes (including known X-box regulated genes) that encode putative components of ciliated neurons in C. elegans and are subject to...
ORGANISM(S): Caenorhabditis elegans 
2008-06-14 | E-GEOD-6563 | biostudies-arrayexpress
TranscriptomicsGlobal gene expression analysis of anthracycline-resistant breast cancer cell lines
Drug resistance in breast cancer is the major obstacle to a successful outcome following chemotherapy treatment. While upregulation of multidrug resistance (MDR) genes is a key component of drug resistance in multiple cancers, the complexity and hierarchy of non-MDR driven drug resistance pathways a...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54326 | biostudies-arrayexpress
TranscriptomicsAlterations in tumour necrosis factor signaling pathways associated with cytotoxicity and resistance to taxanes in tumour cells.
The taxanes are widely used in the treatment of breast and other cancers. While their cytotoxicity has been attributed to the induction of cell cycle arrest in mitosis through the stabilization of microtubules, we found that docetaxel promotes soluble tumor necrosis factor alpha (TNF-alpha producti...
ORGANISM(S): Homo sapiens 
2011-12-30 | E-GEOD-26129 | biostudies-arrayexpress
UnknownA rare missense variant in the ATP2C2 gene is associated with language impairment and related measures.
Not available
S-EPMC8188402 | biostudies-literature
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